The Effect Of Acupuncture And Moxibustion On Prefrontal Cortex Of Patients With Severe Depression Based On Functional Near-infrared Spectroscopy

Object:In the treatment of depression, Acupuncture and moxibustion has less adverse reactions compared with antidepressant treatment, but the mechanism is not clear. We used near-infrared brain function detection technology to study the effect of acupuncture on prefrontal cortex of patients with severe depression, and to discuss the mechanism of acupuncture and moxibustion in the treatment of depression.Methods:We collected outpatients and inpatients with depressive disorder, according to inclusion criteria and exclusion criteria, a total collection of 20 patients during January 2014 to March 2015 in Affiliated Hospital of Chengdu University of Traditional Chinese Medicine and Sichuan Provincial People’s Hospital Department of psychosomatic medicine. They were randomly divided into two groups,10 cases using the acupuncture treatment,2 cases lost; 10 cases using western medicine lexapro oral treatment,2 cases lost. Data analysis were included a total of 16 cases. All cases of two groups were treated for 8 weeks,1 months follow-up. Using SPSS 20 statistical software for data processing. The changes of HAMD-17, BDI-Ⅱ scores with acupuncture group and Western medicine group were compared. At the same time, we used the near infrared brain function detection instruments to collect the dorsolateral prefrontal regions blood oxygen saturation level of patients when they were doing neuropsychological tasks. To analysis the relativities of prefrontal blood oxygen saturation level and depressive disorder degree.Exploring the effects of acupuncture in the treatment of depressive disorder on prefrontal dorsolateral area.Results:1. Analysised the comparison of two groups of age, gender, duration of general data,P>0.05,it showed no significant differences. After treatment, the HAMD-17, BDI-Ⅱ scores of acupuncture group and Western medicine group were all decreased in the first week, the second week, the fourth week, the eighth week, during the follow-up period, and the differences between the them showed no statistical significance. At the same time, the probability of oral medicine adverse reactions and severity were higher than that of acupuncture group.2. After treatment, the correct rates with emotional pictures of acupuncture group and medicine group were all increased, the difference between them had no statistical significance. Dorsolateral prefrontal regions blood oxygen saturation levels with emotional picture collection of acupuncture group and Western medicine control group in different treatment cycles were increased, the differences between them had no statistical significance. The blood oxygen saturation levels of dorsolateral prefrontal regions by near infrared brain function detection technology with the rest of two neuropsychological tasks did not show a very clear regular result.3. We tried the pairwise correlation analysis. The changes of HAMD-17 scores and the dorsolateral prefrontal regions of blood oxygen saturation levels with emotional picture collection were significant correlation, the correlation coefficient were -0.601; the changes of BDI-Ⅱ scores and the dorsolateral prefrontal regions of blood oxygen saturation levels with emotional picture collection were significant correlation, the correlation coefficient were -0.587; the changes of HAMD-17 scores and the BDI-Ⅱ scores were significantly correlated, correlation coefficient were 0.829.Conclusion:1. The patients with depressive disorder were improved after the treatment of acupuncture and Western medicine. The probability and severity of adverse reaction of oral western medicine were significantly higher than that of acupuncture group.2. The relationship of dorsolateral prefrontal regions of blood oxygen saturation level with emotional pictures and HAMD-17 scores showed that, acupuncture may treat depressive disorder patients through improving the function of dorsolateral prefrontal regions.