Overexpressions Of MiR-212 Are Associated With Poor Prognosis Of Patients With Pancreatic Ductal Adenocarcinoma

Objective:To investigate the expression of miR-212 in PDAC and evaluate its correlation with major clinicopathologic features and patients’ survival.Methods:Fluorescence in situ hybridization(FISH)was adopted to examine microRNA(miRNA)expression in 45 pancreatic cancer and 20 normal pancreatic tissues.The relationship of miRNA-212(miR-212)expression with clinicopathologic parameters and clinical outcome was evaluated.ResultsMiR-212 was confirmed to have significantly higher expression in pancreatic ductal adenocarcinoma(PDAC)compared with normal pancreatic tissues(51.1%vs 10%,p<0.01).High expression of miR-212 was significantly associated with tumor size(p=0.048)and tumor stage(p=0.023).Moreover,in univariant analysis,patients with high expression of miR-212 demonstrate significantly poorer overall survival(p=0.02).Conclusion:High expression of miR-212 in PDAC is associated with shorter overall survival.It may be not only a potential prognostic marker,but also a possible therapeutic target in PDAC.