| ObjectiveUsing High resolution magnetic resonance imaging(HRMRI)to explore whether intracranial atherosclerotic plaque features are associated with Essen stroke risk score(ESRS),and to explore whether there is a correlation between ESRS and the type of yin and yang of the patients with acute ischemic stroke.Methods1.In this study,60 cases of hospitalized ischemic stroke patients in total were selected from those patients who were treated in Traditional Chinese Medicine Hospital of Guangdong Province from August 2012 to February 2017.2.Two researchers who had gained knowledge of Essen stroke risk score(ESRS)evaluated the 60 cases and then divided them into the ESRS ≤3 group(high risk recurrence group)and ESRS<3 group(low risk recurrence group).3.The responsible blood vessels of all the selected patients in this study were examined by HRMRI.The plaque components and the arterial wall of intracranial cardiovascular vessels was evaluated by two experienced neuroimaging physicians.The arterial wall of a normal person is thin or not shown.The arterial wall of a atherosclerosis patient shows different degrees of wall thickening.Those whose arterial wall is more clear than normal person and no eccentric thickening is known as intimal thickening.Those whose arterial wall has partial eccentric thickening is known as plaque.The plaque components were identified by HRMRI imaging in the signal strength of each sequence.4.Analysis comparatively whether there was statistical significance among the stroke risk factors when compare high risk recurrence group with low risk recurrence group.And analyze whether plaque stabilization in patients with plaque between high risk recurrence group and low risk recurrence group was statistically significant.5.Compare the risk factors of stroke recurrence with yin and yang type of-the 60 cases,and try to find the relationship between ESRS and the type of yin and yang.Results1.60 cases of ischemic stroke patients were involved in this study.There was 26 cases in ESRS≥3 group,and 34 cases in ESRS<3 group.Among the risk factors,the age of ESRS≥ 3 group was older(70.31±9.63)than ESRS<3 group(54.94±11.17),and the comparison was statistically significant(P<0.05).In ESRS≥3 group,88.5%patients were suffering from hypertension,69.2%patients were suffering from diabetes mellitus.And TIA or ischemic stroke history accounted for 26.9%.Other cardiovascular history accounted for 23.1%,and those data was obviously higher than that of ESRS<3 group(P<0.05).When compared age,the incidence of history of myocardial infarction,peripheral vascular disease,and smoking,there was no Statistical significance between two groups(P>0.05).The comparison of total cholesterol,triglyceride,low density lipoprotein cholesterol levels between two groups was no Statistical significance(P>0.05)either.Five risk factors including age,hypertension,diabetes mellitus,history of TIA or ischemic stroke,and other cardiovascular disease were incorporated into multi-factor unconditional Logistic regression equation.Except other cardiovascular disease,the remaining 4 factors was statistical significant between two groups(P<0.05).Diabetes mellitus had the highest degree of correlation with high risk group(OR=739.33,P=0.012).Followed by history of TIA or ischemic stroke(OR = 416.12,P = 0.019),hypertension(OR = 48.13,P = 0.030),age(OR = 1.42,P = 0.012).2.Among 60 cases of ischemic stroke patients in this study,there was 48 cases of obvious plaques,9 cases of intima thickening,and 3 cases of normal vascular wall.Among 48 cases of obvious plaques,21 cases came from ESRS≥3 group,including 15 cases of unstable plaque and 6 cases of stable plaque.27 cases came from ESRS<3 group,including 11 cases of unstable plaque and 16 cases of stable plaque.The comparison of unstable plaque of the two group was statistical significant(P<0.05).The factor of plaque stabilization was further analyzed by univariate unconditional logistic regression with an OR of 3.636,P<0.05.1.Among 60 cases of ischemic stroke patients in this study,there was totally 23 cases of branch arterial infarction and 37 cases of other type.17 of the 23 cases were observed responsible vascular plaque formation through HRMRI,5 of 23 cases intimal thickening of responsible blood vessels,and 1 case whose responsible vascular wall was normal.3.Among 60 cases of ischemic stroke patients in this study,there was totally 23 cases of branch arterial infarction.17 of the 23 cases were observed responsible vascular plaque formation through HRMRI,5 of 23 cases intimal thickening of responsible blood vessels,and 1 case whose responsible vascular wall was normal.4.Among 60 cases of ischemic stroke patients in this study,there was 45 cases of yin.type and 15 cases of yang type.In ESRS≥3 group,there was 5 cases yang type and 21 cases yin type.In ESRS<3 group,there was 10 cases yang type and 24 cases yin type.There was no statistical significance between the high risk group and the low risk group(P>0.05)when compared the yin and yang type of ischemic stroke.When compared yin type and yang type,age had statistical significance(P<0.05).There was no statistically significant difference among other stroke risk factors(P>0.05).Conclusion1,Intracranial atherosclerotic plaque instability is closely related to the high risk of ischemic stroke recurrent.2.There is no special significance of yin.and yang type between the high risk group and the low risk group,reflecting the core idea "whole concept and dialectical governance" of traditional Chinese medicine.Yin type is more common in ischemic stroke patients.And the average age of yin type patients is slightly larger than patients with yang type. |
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