Study On Adhesion Of Simvastatin Intestinal Patch

Simvastatin has the function of reducing blood lipids,and it can be eliminated quickly and absorbed well in the small intestine.Hyperlipidemia can cause a variety of cardiovascular disease and seriously threaten human life.Blood lipid synthesis reached the peak value in the morning.Therefore,this study used simvastatin as a raw material,and studied the simvastatin enteric adhesion pulse delivery system according to the principle of Chrono pharmacology.The screening process and pulse tablet core coating process,through single factor and orthogonal experiment study method,establish the quality evaluation method of simvastatin tablets intestinal adhesion type pulse,improve the bioavailability of the dosage,reduce the dosage,reduce the toxic side effect.Tablet core prescription process:quick release tablet core prescription,5%simvastatin(40%simvastatin-F68 solid dispersion),20%PVPP,24%starch and 16%dextrin were mixed with Mix equal incremental method.Then add appropriate amount of hard pressed tablets and Magnesium magnesium,tablet core hardness of 6-7N,tablet weight 300mg/tablets.Intestinal adhesion sustained-release tablet formulation,6.75%simvastatin,24.75%carbomer and 1%magnesium stearate were mixed with Mix equal incremental method to obtain powder.After that we made the release film core,100mg sustained-release tablet core powder into the next red,tablet,tablet weight 400mg/tabletsin press machine.Add acrylic resin into 95%ethanol and keep stirring.After they all dissolved,adding ethyl cellulose and PEG6000,stirring three hours and we will get the coating solution.The core is placed in the coating pan with 40?,and when the temperature of the tablet is 40? we will get pressed pulp.The speed is adjusted to 18Hz then the coating will be finished.Remove the tablets before hot incubation for 20 min.The prescription process reproducibility is good,time lag 4h,in line with the experimental program design requirements.The prescription has good reproducibility,meet the expected effect,through the implementation of delayed release coating,using quick release tablet the medicine is an ideal blood drug concentration in blood lipid synthesis of maximum amount,the use of tablet core stable blood drug concentration,preventing the incidence of patients with intestinal mucin,reduce the dosage,reduce the side effects of simvastatin for intestinal adhesion type pulse tablets and utilization of the foundation.