| Obgective:To provide a theoretical basis for correctly clinical intervention,reduce the incidence of FGR and improve the health of infants,this paper discusses the risk factors of fetal growth restriction(FGR),as well as effect on the outcome of perinatal.Methods:FGR were retrospectively analyzed,who had been treated at the Army General Hospital from July 2011 to March 2016.According to diagnostic standard of FGR,and all of the 213 cases of pregnant women were selected as FGR group,at the same time,healthy pregnants and infants(in the last or next case of the FGR group)were deliveried(including induction of labor)and selected as control group.To analyze the risk factors of FGR,and different gestational age,delivery time,effects of delivery way on perinatal outcome,this paper collected basic information,including maternal name,age,history of maternal pregnancy,pregnancy weeks.The pregnancy situation: pregnancy complications,childbirth complications,delivery time,mode of delivery,neonatal birth weight,neonatal outcome and other clinical data.Results:1.The incidence of FGR in our hospital is 1.92 %,which is lower than that reported of our country(6.39 %);171 cases were diagnosed by prenatal ultrasound,42 cases were diagnosed after delivery,and the prenatal diagnosis is 80.28 %.2.As for the FGR and control groups pregnant women age,gravidity,parity,gestational age difference were not statistically significant(P>0.05).The incidence of gestational hypertension,abnormal amniotic fluid and abnormal vasa umbilicalis among FGR group were significantly higher than the control group.The difference was of statistical significance(P<0.05).With the gestational hypertension,the risk of FGR pregnant women is 2.523 times as high as women without gestational hypertension.For the abnormal amniotic fluid,the risk of incidence of FGR is 2.496 times as high as women with the normal amniotic fluid,abnormal vasa umbilicalis was diagnosed,the risk of incidence of FGR increased by 4.297 times.3.213 cases of FGR were divided into early-onset group(incidence of pregnancy week ≤ 32 weeks),and late-onset group(incidence of pregnancy week>32 weeks),The main factors of early-onset group were gestational hypertension and abnormal vasa umbilicalis,in the late-onset group,the main factor was abnormal amniotic fluid.The incidence of gestational hypertension and abnormal vasa umbilicalis were significantly higher than that of the late-onset group.The difference was of statistical significance(P<0.05).The 1 min Apgar score,5 min Apgar score,10 min Apgar score and neonatal weight in the late-onset group were obviously higher than in the early-onset group,and the difference was of statistical significance(P<0.05).The morbidity and perinatal mortality were higher in the early-onset group,but only the death rate of perinatal infants was statistically significant(P <0.05).4.According to the gestational age of delivery,FGR group was divided into three groups:the first group was ≤33+6 weeks,the second group was 34-36 +6 weeks,the third group was 37-42 weeks,the neonatal weight of each group were 1455.8±369.2、2053.3±325.5、2611.3±393.5,the third group was the highest,the difference was of statistical significance(P<0.05),neonatal asphyxia(the incidence of each group were 12.5 %、6.45 %、1.35 %),pediatric hospital admission rates(the incidence of each group were 75 %、70.97 %、24.32 %),the death rate of the perinatal infants(the incidence of each group were15.79 %、8.82 %、0.67 %),compare each rates were visible significant difference(P<0.001).5.FGR group has a high rate of cesarean section,in which emergency cesarean section is 79 cases,and elective cesarean section is 69 cases.For statistics of surgical indications,the intrapartum fetal distress is the main cause of the high rate of emergency cesarean section.Conclusion:1.The incidence of FGR in our hospital was 1.92 %,and the prenatal diagnosis was 80.28 % from July 2011 to March 2016.2.Gestational hypertension,abnormal vasa umbilicalis and abnormal amniotic fluid were the risk factors for FGR.3.The early-onset FGR is characterized by high complications that lead to poor outcomes.In order to improve the prognosis of the newborn,rationally manage early-onset FGR is important.4.Gestational age is a key factor affecting the outcome of FGR perinatal.Conditions of mother and child permitted,extend the gestational age is appropriate.According to the principle of individual,timely and appropriate way to terminate the pregnancy is conducive to improve the quality of children’s life. |
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