| Objective: To observe the clinical effect of Zishenshugan method in treating decreased ovarian reserve among shenxuganyu,to explore the way of thinking and method of Traditional Chinese Medicine treatment on it,and to promote the inheritance and development of Traditional Chinese Medicine.Method: 60 cases who met the inclusion criteria were randomly divided into two groups.(1)The treatment group: 30 cases were treated with traditional Chinese medicine(Zishentiaogan).(2)The control group : 30 cases were treated with simple western medicine(Complex Packing Estradiol Valerate Tablets,Estradiol Valerate and Cyproterone Acetate Tablets).In a menstrual cycle,for a period of treatment,taking three consecutive period of treatment.Two groups of patients were observed before and after treatment of menstrual conditions,changes in clinical symptoms,and records them in the TCM syndrome score table;Records of pregnancy situation;2-3 days based sex hormone levels during the menstrual cycle,number of antral follicles,ovarian volume.What is more,adverse drug reactions were observed and recorded.Using its own statistical analysis of comparison between groups before and after contrast to observe different treatment on the ovarian function of patients with decreased ovarian reserve.Results:(1)Menstruation efficacy: After 3 menstrual cycles of treatment,the total effectiveness was 88% in the treatment group,and 42.31% in the control group.Comparing the efficacy of menstruation in the two groups,there was a extremelysignificant difference through chi-square test(P<0.01).(2)Clinical symptom efficacy:After treatment,the total effectiveness was86.67% in the treatment group,and 66.67% in the control group.Comparing the efficacy of Clinical symptom in the two groups,there was a remarkable difference through chi-square test(P<0.01).(3)Pregnancy efficacy:The treatment is finished,the total effectiveness was16.67% in the treatment group and control group.Comparing the efficacy of pregnancy in the two groups,there was no statistically significant difference through Fisher,s exact probability test(P>0.05).(4)The clinical efficacy: The treatment group of 30 patients,the total efficiency was 93.33%.The control group of 30 patients,the total efficiency was70%.Comparing the total effects in the two groups,there was a extremely significant difference through chi-square test(P<0.01).(5)Hormone level: Compared the patient before and after treatment in the same team,b-FSH,b-LH,the normal region FSH/LH level and b-E2 had a obvious effect(P<0.01)in both group.While there was no effect for the high region FSH/LH level(P>0.05).Compared the treatment group with the control group,the treatment group adjusted the FSH/LH level was more significant(P<0.01),other fields was no statistically significant difference through chi-square test(P>0.05).(6)Ovarian volume: After therapy,compared the patient before and after treatment in the same team,the treatment group was effective for the small(P<0.05);The control group made no change both in small and normal(P>0.05).Compared the treatment group with the control group,the effect was considerable(P>0.05).(7)Number of antral follicles:After treatment,compared the patient before and after therapy in the same team,traditional Chinese medicine and Climen could increase the number of antral follicles(P<0.05).Compared the treatment group with the control group,the effect was no statistical significance(P>0.05).Conclusion: The effect on the treatment of Zishenshugan method upondecreased ovarian reserve patients was significant,could significantly adjusted menstruation,improved the Shenxuganyu clinical,significantly decreased the high b-FSH and b-LH,adjusted the FSH/LH,had two functions on b-E2,one was reduced the high b-E2,the other was increased the low b-E2;It also could enlarged the small ovarian volume,gained the number of antral follicles.The total efficiency was 93.33%,the efficacy was statistically significant compared with the control group.It proved that traditional Chinese medicine could effectively improved ovarian function on DOR patients,worth to clinical application and further research. |
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