Clinical Observation On The Coagulation State And Clinical Effect Of The Coloclyster’s Prescription Of Changyu In The Patients With Ulcerative Colitis(Rectum) In The Active And Damp Heat Type Of Large Intestine

Objective : To observe the effect of the changyu enema’s prescription on the blood coagulation and clinical efficacy of patients with active ulcerative colitis(rectal type)by retention enema.Method: select 66 patients with ulcerative colitis(rectal type)were diagnosed by the combination of traditional Chinese and Western Medicine.who were randomly divided into treatment group and control group with 33 cases in each group,the treatment group was treated by changyu enema’s prescription,and the control group was treated by Mesalazine suppository.observ the changes of coagulation related indicators(PLT,PT,D-D,MPV,Fib),ESR,CRP,clinical efficacy and TCM syndromes before treatment and first month and second month after treatment.Result:After the first month of treatment,the treatment group and the control group were significantly lower than before treatment in Mayo score,TCM syndrome score,PLT,D-D,Fib,ESR,CRP.and the difference was statistically significant(P<0.01).MPV and PT in two groups were significantly higher than before treatment,and the difference was statistically significant(P<0.01).The comparison between the two groups showed that there was no significant difference between the two groups in Mayo score,TCM syndrome score,comprehensive efficacy,TCM syndrome efficacy,D-D,Fib,ESR,CRP(P>0.05).Compared with the treatment group,the MPV and PT increased significantly in the control group(P<0.05).and the PLT in the control group was significantly lower than that in the treatment group(P<0.01).After the second month of treatment,the treatment group and the control group were significantly lower than before treatment in Mayo score,TCM syndrome score,PLT,D-D,Fib,ESR,CRP.and the difference was statistically significant(P<0.01).MPV and PT in two groups were significantly higher than before treatment,and the difference was statistically significant(P<0.01).The comparison between the two groups showed that the treatment group’s comprehensive efficacy and TCM syndrome efficacy were higher than the control group(P<0.01).The Mayo score,D-D,ESR and CRP levels in the treatment group were significantly lower than the control group(P<0.05).TCM syndrome score,PLT and Fib in the treatment group were significantly lower than the control group(P<0.01).The MPV of the treatment group was higher than the control group(P<0.01),and the treatment group was better than the control group in prolonging PT(P<0.05).Conclusion:The changyu enema’s prescription was clinically effective in patients with active ulcerative colitis(rectal type)in large intestine,and it can improve the hypercoagulable state of patients,and the longer treatment time,the more obvious effect.