Different Expression Patterns Of β-catenin And Its Clinical Significance With Clinic-pathological Manifestations In Colorectal Cancer

Objects: To detect the expression pattern of β-catenin in colonical carcinoma tissues,and study discussing the relationship between the expression of β-catenin and the clinico-pathologic characteristics of colorectal cancer;systematically analyzing the function and significance of β-catenin in the occurrence and development of colorectal cancer.Methods: We selected the specimens of 30 cases of normal mucous membranes and 181 cases of colorectal cancer which were excised by the pathology department of the First Affiliated Hospital of Anhui Medical University from Nov.2007 to Dec.12.The methods of formalin fixation and paraffin imbedding were applied.We used the immunohistochemical method to detect the expression level of β-catenin in them,and also made use of SPSS 21.0 to make statistical analysis of the data.Results: In the 181 colorectal cancer tissues,β-catenin(cell nucleus)occupies 56.9%(103/181),which is higher than that in the normal mucosa(P<0.05).The expression of β-catenin(cell nucleus)is related with the differentiated degree,lymphatic metastasis and clinical Duke’s stag(P<0.05),but not with the ages,genders,infiltration depth and other clinico-pathologic characteristics.The incomplete expression of β-catenin cytomembrane is related with tissue differentiation,infiltration depth of tumor,lymph node metastasis status and Duke’s stagings(P<0.05),while the over-expression of β-catenin relates with the differentiated degrees of colorectal cancer tissues and Duke’s stagings(P<0.05).In the follow-up cases of 82 people,the patients with positive expression of β-catenin nucleus have a lower 5-year survival rate than that in the control group(P<0.05)Conclusion: β-catenin has a big effect on the occurrenceand development of colorectal cancer.The different expression patterns of β-catenin have correlation with the development of colorectal cancer.It will have a great influence on the prognosis to intensively study the regulatory mechanism.β-catenin is expected to become a new target for genetic diagnosis and treatment of colorectal cancer.