| Background:Primary bronchogenic carcinoma,lung cancer for short,refersto malignant tumor originated in the bronchial mucosa or gland.The incidence of lung cancer is high in the modern world,and the number of patients with lung cancer is increasing in China.For now,cancer is thesecond major reason of death in the world population.According to the recent datashows in China,the incidence of lung cancer increased year by year,the mortality of lung cancer increased obviously.Lung cancer has become theleading cause of cancer death.Lung cancer is divided into small cell lung cancer(SCLC)and non-small cell lung cancer(NSCLC).In the treatment,small cell lung cancer is more sensitive to the chemotherapy and radiotherapy,so these are the maintreatment method.The treatment of NSCLC needs to take the tumor histology,tumorstage and patient’s own characteristics and other factors into consideration.Although the improvement and innovation of the treatment technology,the early diagnosis of lung cancer is still difficult,and the treatment of NSCLC is still hard for aqualitative breakthrough.Therefore,to improve the quality of life and the survival timeof patients with comprehensive treatment methodsis still the main objective atpresent.The traditional Chinese herbs with its unique overall concept and treatment based on syndrome differentiation thought,advocate the anticancer,take Fuzheng and Quxie combination,reduce the side effects of chemotherapy and delay the development of tumor,the treatment of lung cancer,fundamentally,to prolong the survival time,gradually recognized by people.Objective: Master Xie committed to the study of Chinese medicine for many years and is rich in experience and practice.He put forward the treatment mode of improving the quality of life and survival with tumor formed by expelling of noxious substance by vital qi gradually,adjusting the internal environment of the body,suppressing the spread of tumor development to get along with the tumor harmoniously without mutual invading and harassing.Xieshi lung cancer No.Three in the treatment of NSCLC has a significant effect on inhibiting tumor,reducing tumor,relieving the toxic and side effects of radiotherapy and chemotherapy,enhancing immunity and prolonging the survival time of cancer patients.In order to further verify the research and application on clinic,this experiment is specially built.In this study,Lewis was used to establish the animal model of NSCLC and was intervened,and the apoptosis rate and proliferating nuclear antigen data were calculated.The differences and changes of the specimen are observed by naked eye and to be recorded and analyzed.Methods: 1,The tumor tissue is made into tumor cell suspension,and certain number tumor cell suspension is extracted to give subcutaneous injection to the mice,during which 40 mice need to be injected into,each injection of 0.1ml.2,After the second day,the mice were divided into four groups: the model group,the Xieshi lung cancer No.Three group,the cisplatin group,Xieshi lung cancer No.Three group combined with cisplatin group.3,The four groups were treated with different drugs,once every 24 hours,totaling 14 times,and to be killed after more than 360 hours.To get tumor inhibition rate,apoptosis rate,proliferating cell nuclear antigen through the calculation and measurement.Results:1,The tumor inhibition rate and weight of each group were compared,and the results showed that the tumor inhibition rate and weight of Xieshi lung cancer No.Three group was significantly higher than those of the Xieshi lung cancer No.Three group combined with cisplatin group,the cisplatingroupand the model group(P<0.05).2,Compared with PCNA,there was a significant difference between the Xieshi lung cancer No.Three group and the other three groups,the model group,the cisplatin group and Xieshi lung cancer No.Three group combined with cisplatin group(P < 0.05).3,Compared with the cancer cell apoptosis rate,there was a significant difference between the Xieshi lung cancer No.Three group and the other three groups,the model group,the cisplatin group and Xieshi lung cancer No.Three group combined with cisplatin group(P < 0.05).Conclusion: The results showed that Xieshi lung cancer No.threeCan significantly induce the apoptosis of cancer cells,inhibit the proliferation of cancer cells,which may be one of the antineoplastic mechanisms.Xieshi lung cancer No.threein mice inhibited tumor and improve the quality of life have a significant role. |
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