Voxel-based Resting State FMRI Observation On Changes Of Function Connectivity Of Whole Brain In Multiple Sclerosis And Neuromyelitis Optica

Purpose:Using Voxel-based whole brain functional connectivity of resting state f MRI to analyze the changes of function connectivity of whole brain between multiple sclerosis（MS）and neuromyelitis optica（NMO）.In order to explore the changes of function connectivity of whole brain between these two diseases and healthy people and the difference between the two diseases.Method:Patients were collected: 20 MS patients,14 NMO patients and 14 healthy controls were selected.The T1 WI,T2WI,FLAIR and BOLD-EPI scans were performed by3.0T magnetic resonance scanner.BOLD-EPI was collected without task stimulation,using a resting scan.All data are processed offline.Based on the Matlab2014 b platform,using the spm12 and See CAT software package to preprocess the f MRI data.The functional connectivity of the whole brain gray matter（each voxel）with the rest of the brain area（the remaining voxels）was calculated.Then the strength of whole brain voxel（functional connectivity strength,FCS）were obtained,which is represented by r.The Pos_Wei₀00-Inf_Sub_.nii file is divided into MS group,NMO group and HC group（healthy control group）.Firstly,the average value of each group was calculated by using the See CAT software to analyze the average of total brain functional connectivity in each groups.secondly,the method of one-way analysis of covariance was used to measure the functional connectivity between the three groups of MS group,NMO group and HC group,to compare the whole brain function of the three groups.According to the results of functional connectivity between MS group and NMO group,the relationship and difference between MS group and NMO group were analyzed.Result:1.The three group calculated the total 45381 voxel of function connectivity of whole brain,in the AAL brain standard anatomical template,resting state of the whole brain functional activation area in HC group include bilateral frontal gyrus,temporal gyrus,dorsolateral frontal gyrus,postcentral gyrus,inferior temporal gyrus,precuneus,anterior central back;The resting state brain activation areas of MS group and NMO group are similar to HC group,otherwise,the activation range is enhanced and weakened.2.Compared with the normal control group,in the resting state,the main enhanced areas of MS group of the whole brain function include bilateral cuneus,calcarine cortex,occipital gyrus,lingual gyrus,superior occipital gyrus,inferior occipital gyrus（P<0.05）;weakened regions include: left middle frontal gyrus,right superior frontal gyrus（P<0.05）3.Compared with the normal control group,in the resting state,the main enhanced areas of NMO group of the whole brain function include left fusiform gyrus,bilateral temporal pole:superior temporal gyrus,left temporal pole:temporal gyrus,left hippocampus,left inferior temporal gyrus,right parahippocampal gyrus,Left brain rectus muscle,right frontal gyrus rectus frame gyrus,bilateral caudate nucleus and thalamus（P<0.05）;weakened regions include: left insula,left central sulcus cover（P<0.05）.4.There are no significant difference in the enhancement of the whole brain functional area between the NMO group and the MS group.But the weakened area was statistically significant,the weakened areas include bilateral calcarine cortex,left occipital gyrus,bilateral postcentral gyrus,bilateral central sulcus cover,left precentral gyrus（P<0.05）.Conclusion:1.There are not only potential function weaken in MS patients of function connection of whole brain,but also functional connection enhance;2.There are not only potential function weaken in NMO patients of function connection of whole brain,but also there are functional connection enhance.;3.There are differences in the activation of function connectivity of whole brain between NMO patients and MS patients,mainly reduced the connection of the whole brain function;4.Voxel-based whole brain functional connectivity of resting state f MRI can be a good method to study the whole brain function of multiple sclerosis and neuromyelitis optica or other related diseases.