The Study Of Resting State FMRI Changes In Cervical Dystonia Patients Based On Degree Centrality

Objective:As we all know,cervical dystonia(CD)is associated with dysfunction of basal ganglia,but several studies have found that other brain regions involved in patients with CD in recent years,CD pathogenes is remains to be further defined,we adopt degree centrality method to observe the differences of functional connectivity between patients with cervical dystonia and heathy controls,to explore the pathophysiology of cervical dystonia.Methods:21 patients with cervical dystonia and 21 age,sex,and education-matched heathy controls were recruited in this study.By using resting-state functional magnetic resonance imaging(Rs-f MRI)and degree centrality method obtained functional connectivities’ differences,and made correlative research on the degree centrality values with CD patients’ duration and symptom severity(Tsui scores).Results:Compared with heathy controls,the patients with CD had significantly higher degree centrality in bilateral precuneus,and significantly lower in right middle orbital frontal gyru,the abnormal brain regions’ degree centrality values had no correlation with duration and symptom severity of patients.Conclusion:The bilateral precuneus and right middle orbital frontal gyru are involved in the pathophysiology of CD’ involuntary movement or regulatory mechanism disorder,and the course,the symptom severity of patients may not be affecting the connection strength between brain areas.