Study Of Wound Pathogenic Culture And Antimicrobial Resistance Before And After Infection In Fresh Open Fractures

Objective To explore the situation of wound pathogenic culture and antimicrobial resistance(AST)before and after infection in open fractures,aiming to guide the use of clinical antibiotics.Methods 42 patients with open fractures from May 2015 to August 2016,in which we did bacterial culture and antimicrobial resistance in emergency surgery and after infection,analyzed the result and correlation.Results In emergency surgery,4 patients were isolated 4 bacterial strains,all of that were enterobacter cloacae and Escherichia coli(E.coli),only in 1 case we found the same bacteria culture in emergency surgery and after infection.There were 40 of patients were isolated 48 bacterias after infection,respectively 14 pseudomonas aeruginosa,12 Escherichia coli,4 Acinetobacter baumannii(Ab),4 Klebs iella pneumoniae(Kpn),2 enterobacter cloacae,6 staphylococcus epidermidis,6 staphylococcus aureus,in which gram-negative bacteriums accounted for 75%(36/48).Cefoperazone and levofloxac in were sensitive to the major pathogenic bacterias,resistant rate<35%;6 multiple resistant bacterias(MDR)were isolated and resistant to general antibiotics.Conclusion Results of the bacteria culture from the wounds in emergency surgery could not speculate the pathogenic bacteria that caused ultimate infection.Gram-negative bacterium gave rise to the infection in open fractures.We should control nosocomial infection well because there were quite a few MDR.It was necessary to adjust the antibiotics according to the pathogenic culture and antimicrobial resistance of pathogens when patients were infected,it was important for prevention and control of the clinical infection.