Analysis Of Influencing Factors On Quality Of Life Of Patients With Systemic Sclerosis

Objective:To study the factors influencing the quality of life of patients with systemic sclerosis(SSc)and their relevance to disease activity and severity.To improve the quality of life of patients with SSc,to evaluate the overall status of SSc and to select appropriate treatment Provide theoretical basis.Methods:Collected from November 2015-October 2016 in Guangxi Medical University First Affiliated Hospital of Rheumatology Department of rheumatology or outpatient treatment of systemic sclerosis in 68 patients,selected 30 healthy controls,the use of cross-sectional questionnaire method,SSC patients were divided into diffuse skin system sclerosis and localized skin sclerosis.The MOS-36 Item Short-Form Health Survey(SF-36),Health Assessment Questionnaire(HAQ),Visual Analogue Scale(VAS)and the St.George ’ s Respiratory Questionaire(SGRQ)and Modified Rodman Skin Score(MRSS)were used to assess the quality of life of patients with SSc and to analyze their association with clinical indicators.Results:1.A total of collected demographic and clinical features of 68 cases of SSc patients as follows: mean age(52.26 ± 10.66)years,mean disease duration(35.25 ± 47.79)months,38 females(55.9%)patients,8(11.7%)cases ofsmoking,54(79.4%)cases dcSSc.Wherein the presence of 59(87.8%)patients with Raynaud’s phenomenon,9(13.2%)of finger ulcer cases.16(23.5%)patients presented with PAH.ESR(41.38 ± 28.79)mm/H,CRP(25.78 ± 38.81)mg / L,ANA positive 64(94.1%)cases,anti-Scl-70 antibody positive 59(87.8%)cases.2.SSc patients in the SF-36 scale score physiology(63.97 ± 28.71)points,physical function(53.31 ± 33.15)points,bodily pain(66.06 ± 19.38)points,social function(53.31 ± 19.52)points,in general(58.03 ± 23.71)points,energy(52.87 ± 17.92)points,emotional function(46.58 ± 35.11)points,mental health(45.29 ± 20.90)scores were lower than the control group,all P <0.05,but no difference between a change in health The SSc patients HAQ scale scores(1.13± 0.79)points,VAS scale score(3.22 ± 1.31)points,SGRQ symptom scale division(44.39 ± 19.16),sub-activity(50.26 ± 14.30),impact points(53.69 ±19.03),the total average(49.39 ± 15.67),were significantly higher than the control group,all P <0.05.3.Compared with IcSSc patient,the patient dcSSc of SF-36 in the physiological function(P = 0.030),physical function(P = 0.033),bodily pain(P= 0.032),energy(P = 0.008),and other fields Score decreased;no significant difference between the two groups in the fields of general,social function,role emotional,mental health,health changes.dcSSc patients HAQ,VAS scale scores were significantly higher than IcSSc patients(both P = 0.000),SGRQ symptom scale points,sub-activities,impact,and the total average area is substantially equal to the score between the two groups(all P> 0.05).4.multiple stepwise regression analysis,SSc patients in the SF-36 scale assessment were physiological function,physiological function,physical pain,social function,general situation,energy,emotional function,mental health asthe dependent variable,clinical and laboratory indicators The factors that influence the physiological function of SF-36 scale in SSc patients were: HRCT score,MRSS,C3.The factors influencing the physiological function were:MRSS,HRCT score,C3;The factors influencing the physical pain were: the Renault phenomenon and the MRSS;The factors influencing the social function were: HRCT score,MRSS,C3;the factors that affected the general situation were: HRCT score,MRSS,smoking;the factors that affected the energy were :MRSS,HRCT score,C3;affect the emotional function of the factors were:HRCT score,MRSS;affect the mental health factors were: HRCT score,MRSS,C3.5.The scores of HAQ in the SSc score,the VAS scale score,the symptom scores,the influence points and the activity points were the dependent variables.The clinical and laboratory indexes were closely related to the above indexes,and found that 1)The scores of HAQ scale were: Raynaud’s phenomenon,MRSS;2)The factors that affected VAS scale were: MRSS,Renault phenomenon,joint pain;3)The factors that affected the symptoms of SGRQ score in SSc patients were The scores of HRCT score,duration of disease,smoking,and activity were as follows: HRCT score,smoking,and influence factors were HRCT score and smoking.Conlusion:1.SSc patients in the field of physical health and mental health quality of life was significantly lower than normal,limited mobility,increased physical pain,respiratory symptoms were significantly higher than normal people.2.Compared with Ic SSc patients,dcSSc patients in the physiological function,physiological function,physical pain,energy and other quality of lifedecreased physical activity decreased physical activity increased significantly,and no significant differences in respiratory symptoms.3.The quality of life of SSc patients was significantly correlated with smoking,duration of disease,ILD,degree of skin sclerosis and complement C3,and body pain was associated with Renault phenomenon,skin sclerosis and joint pain.