Effects Of Different Exercise Modes On Changes Of Glucagon-like Peptide -1 In Prediabetic Subjects

Objective: To observe the effects of 18 months of aerobic exercise and resistance exercise on glucagon-like peptide-1(GLP-1), blood glucose, blood lipid, and body mass index(BMI) in prediabetic patients, and analyze the correlation between the GLP-1 levels and blood glucose, blood lipid, BMI.Investigate the effects of GLP-1 on the diabetic transformaition process, explore a more effective, more convenient, and more suitable exercise mode for prediabetic subjects, in order to achieve the purpose of prevention and control of diabetic mellitus.Methods : According to the diagnostic criteria of prediabetes about American Diabetes Association in 2012, the study adopted a randomized method and randomly divided prediabetic sbjuects under the criteria for the inclusion and exclusion into group A, group B, and group C. Subjects in the group A received moderate-intensity aerobic exercise, in the group B received resistant exercise, and there was no intervention in subjects of group C. Before intervention and at 3, 6, 12, and 18 months of intervention, serum GLP-1,fasting blood glucose(FPG), 2-hour postprandial Glucose(2hPG), total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C), and BMI were detected in the three groups; the change range of 18months of serum GLP-1 and the range of blood glucose, blood lipid, BMI were calculated after 18-months intervention.Results:?. Compared with the baseline, GLP-1 was increased in the group A at 12 and 18 months of intervention, which was decreased at 6 months and was increased at 18 months in the group B, and that was decreased in group C at 6,12 and 18 months(all P< 0.05); after 18-months intervention, GLP-1 increased more in both group A and group B than in group C(P<0.05).?. Compared with the baseline, HbA1c was decreased in the group A at 3,12 and 18 months of intervention, which was decreased in the group B at 3, 6,12 and 18 months of invention, and that was increased in group C at 6, and 18 months(all P<0.05); after 18-months intervention, HbA1c decreased more in both group A and group B than in group C(P<0.05).?. Compared with the baseline, FPG was decreased in the group A at 3, 6,12 and 18 months of intervention, which was decreased in the group B at 3 and 18 months of invention, and that was increased in the group C at 18 months(all P<0.05); after 18-months intervention, FPG decreased more in both group A and group B than in group C(P<0.05).?. Compared with the baseline, 2hPG was increased in the group C at 3 months of invention(P<0.05); after 18-months intervention, 2hPG decreased more in group A than in group C(P<0.05).?. Compared with the baseline, TC was decreased in the group A at 12 and 18 months of intervention, which was decreased in the group B at 12 and 18 months of invention, and that was increased in the group C at 6 and 18 months(all P<0.05); after 18-months intervention, TC decreased more in both group A and group B than in group C(all P<0.05).?. Compared with the baseline, TG was decreased in the group A at 18 months of intervention, which was increased in the group C at 3 and 6 months(all P<0.05); after 18-months intervention, TG decreased more in both group A and group B than in group C, and that decreased more in group A than in group B(all P<0.05).?. Compared with the baseline, LDL-C was decreased in the group A at 3,12, and 18 months of intervention, and that was increased in the group C at 6 and 18 months(all P<0.05); after 18-months intervention, LDL-C decreased more in both group A and group B than in group C(P<0.05).?. Compared with the baseline, HDL-C was increased in the group A at 6,12, and 18 months of intervention, which was increased in the group B at 6, 12 and 18 months of invention,and that was decreased in the group C at 18 months(all P<0.05); after 18-months intervention, HDL-C decreased more in both group A and group B than in group C(P<0.05).?. Compared with the baseline, BMI was decreased in the group A at 3 and 6 months of intervention, which was decreased in the group B at 6, 12 and 18 months of invention, and that was increased in the group C at 3 and 18 months(all P<0.05); after 18-months intervention, BMI increased more in group A than in group C(P<0.05).?. At 18 months of intervention, the change range of HbAlc, FPG, 2hPG,TC or TG was negatively correlated with the change range of GLP-1(r=- 0.499,-0.487, -0.241, -0.451, or -0.310, all P<0.05)Conclusion: i. Both the aerobic and resistant exercise intervention can retard the declining of GLP-1 in prediabetic subjects; ii. The short-term effect of aerobic exercise is superior to that of resistance exercise on GLP-1;?. long-term aerobic exercise and resistance exercise can increase the level of GLP-1, decrease the level of HbAlc, improve the level of blood glucose and blood lipid in prediabetic subjects.