The Effectiveness And Influencing Factors Of ¹³¹I Treated Differentiated Thyroid Microcarcinoma

Objective: To investigate the effectiveness and influencing factors of ¹³¹I treated patients with differentiated thyroid microcarcinoma（DTMC）.Methods: A retrospective analysis was performed on 95 patients with DTMC who were treated with ¹³¹I in the First Affiliated Hospital of Guangxi Medical University from to 2011-2015.All patients were followed up for more than 6 months.Radioiodine whole body scanning,Tg,TgAb,ultrasonography,CT and other imaging examinations were used to evaluate the efficacy of ¹³¹I treatment.Ten factors included gender,age,thyroid surgery,surgery and ¹³¹I treatment interval,lymph node dissection,tumor pathological type,primary tumor diameter,the number of primary tumorcervical lymph node metastasis and distant metastasis that may affect the efficacy of ¹³¹I treatment were analyzed by Logistic regression.Results: The total effective rate of ¹³¹I in the treatment of differentiated thyroid microcarcinoma was 80%（76/95）,the cure rate was（38/95）,and the improvement rate was 40%（38/95）.The effective rate was 19/95.Single factor Logistic regression analysis showed that ¹³¹I treatment of differentiated thyroid microcarcinoma postoperative efficacy and age,patients with neck lymph node dissection,tumor pathological type and distant metastasis were significantly correlated（P < 0.05）,but sex,thyroid surgery,first ¹³¹I treatment and operativeinterval,lymph node dissection,the original tumor diameter,number of primary tumor and cervical lymph node metastases.The correlation was not significant（P >0.05）.The related factors were analyzed by multivariate Logistic regression analysis showed that the factors affecting the efficacy of ¹³¹I in the treatment of patients with differentiated thyroid microcarcinoma were tumor pathological type（P=0.00004）and distant metastasis（P=0.041）.Conclusion: The curative effect of differentiated thyroid microcarcinoma patients received ¹³¹I treatment,pathological type and distant metastasis is the factors affecting the efficacy of ¹³¹I treatment,timely adjust the treatment plan according to the above factors in the treatment process,in order to improve the cure rate of patients with differentiated thyroid microcarcinoma.