| BackgroundMalignant obstructive jaundice is due to malignant tumors caused by direct or indirect biliary obstruction and hyperbilirubinemia,tissue and body fluids yellow dye as the main clinical manifestations of the disease,such as pancreatic cancer,cholangiocarcinoma,duodenal papilla As well as other malignant tumor metastases and relapses against bile ducts,which often cause immune system dysfunction,decreased respiratory function,kidney failure and other serious reactions,greatly increasing the mortality of patients with malignant tumors.Intraperitoneal perfusion therapy is an effective method for the treatment of intraperitoneal malignant tumors in recent years.To explore the effect of intraperitoneal hyperthermic perfusion in the treatment of malignant intestinal obstructive jaundice,which can effectively treat malignant tumors and reduce the complications caused by malignant obstructive jaundice and play an important role in improving the quality of life of patients,and prolonging survival.ObjectiveTo explore the Palliation efficacy of intraperitoneal hyperthermic perfusion for malignant obstructive jaundice,and to provide a new field of view for the treatment of malignant tumors by intraperitoneal perfusion.MethodsSelected 39 patients with cholangiocarcinoma(high and low position),gallbladder cancer,pancreatic cancer and ampulla cancer,who were received general surgery treatment(radical surgery or palliative care)with complete clinical data complete clinical data in Xinxiang Medical College First Affiliated Hospital from July 2015 to October 2016.Then(18 cases,46%)were treated with intraperitoneal hyperthermic perfusion into the treatmentgroup and(21 cases,54%)were not underwent intraperitoneal perfusion into the control group,The two groups of clinical data were retrospectively analyzed to detect the treatment group and the control group of patients before surgery 1 day,1 day after surgery,postoperative day 4,postoperative 7 days serum total bilirubin(Total Bilirubin TBIL),Direct bilirubin(Direct Bilirubin DBIL),serum alkaline phosphatase(Lkaline Phosphatase ALP)correlation index level,using repeated measurement of variance analysis,P <0.05 for the difference was statistically significant.ResultsThrough statistical analysis comparison,patients undergoing intraperitoneal hyperthermia group and those who did not underwent perfusion were exposed to palliation efficacy one day before surgery,there was no significant difference in serum TBIL,DBIL and ALP between the groups.But The levels of serum TBIL in the treatment group were significantly lower than those in the control group(F=12.63,P<0.01),DBIL was significantly lower than that in the control group(F = 26.68,P <0.01)Significantly lower than the control group(F=21.76,P <0.01)ConclusionIntraperitoneal hyperthermic perfusion has effect on palliation efficacy for malignant obstructive jaundice. |
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