Individual Differences Of White Matter Pain Pathway In Migraine Patients Based On Probability Tracking Method

Migraine is a common type of the headache,which is the dysfunction of nerve andvessel,characterized as the repeated episodes of one or two sides headache usually companied with nausea and vomit.Frequent migraine attacks may have an enormous impact on both the individual sufferer and society as a result of pain,environmental sensitivity or disability.Repeated headache can cause serious complications,which bring to patients with great psychological pain and economic burden.The study of central injury in patients with migraine is mainly focused on local morphological differences,but there are few studies on the pathways of the transmission of white matter fibers.Migraine patients with pain for the abnormal transmission of white matter seriously affect their late clinical efficacy,the different damage of white matter pathways may lead to the different treatment effect on the latter part with the same clinical intervention for patients.Individual differences of the white matter pathways in migraine patients contribute to better design of treatment regimens.This paper attempts to investigate the correlation between white matter damage and headache activity in migraine patients.Based on this,we selected the seed points to analyze the effect of individual differences on the white matter pathways.Therefore,the specific work of this paper is as follows:(1)Using the method of diffusion tensor imaging to collect the imaging data of migraine patients and their healthy control group,and based on the m of Tract-Based Spatial Statistics(TBSS),analyze the local white matter damage of the migraine patients was compared with the healthy control group,and study the correlation between fractional anisotropy(FA)and headache activity in the whole brain.To investigate the brain region which have the significant correlation between migraine patients and clinical indicators.On the basis of this,we further explored the interaction between the the individual differences brain region of migraine patients and healthy subjects and the brain regions associated with clinical indicators,then discussed the effects of white matter damage in migraine patients.(2)Aiming at the above-mentioned brain regions of migraine patients,the seed points were selected to track based on probabilistic tracking method,and the correlation between FA value and volume of fiber bundle was analyzed.The brain region with significant correlation was selected for secondary probability fiber tracking,and the correlation between the volume of the bundle and the headache was analyzed,and the impaired white matter pathway was found in the migraine patients compared with the healthy control group.Consistent with previous migraine study findings,our TBSS analysis revealed the genu,body,splenium part of corpus callosum and corona radiata showed decreased FA values in migraine patient,relative to the healthy controls,which indicating that the intrgrity of these regions has changed.There was a significant correlation between the FA value and the average duration of headache based on whole brain-related results,The brain regions with high correlation were splenium of corpus callosum,corona radiata,anterior limb of internal capsule and posterior limb of internal capsule.The results of the two methods were analyzed to obtain the brain region of interest for fiber tracking.The results showed that there were abnormalities in the white matter pathway between the corpus callosum and the corona radiata,and there was significant correlation with the average duration of headache.The corpus callosum and the corona radiata are located in the painful area of the brain and play an important role in the transmission of pain.This study shows that the white matter pathways in migraine patients have damaged,which provides a theoretical basis for the further study of the pathogenesis of migraine.