| Objective:To investigate the prevalence of type 2 diabetic kidney disease in our hospital,analyze the epidemic characteristics and some potential r isks,which may be helpful for early prevention.Methods: we collected 5890 cases of type 2 diabetic mellitus in our hospital from Jan 1,2014 to Jan 1,2016,after relinquished the cases with repeated hospitalization,lacking of 24 hours urine protein quantitation,blood renal function and other diseases which could lead to kidney damage,4764 cases were enrolled in our study.Retrospective analyze were used to investigate the prevalence of diabetic kidney disease during the past two years.These cases were divided into four different groups:diabetic mellitus while non diabetic kindey disease,the early diabetic kindey disease,the clinical diabetic kindey disease and the end stage diabetic kindey disease according to patients’ s serum creatinine,eGFR,24 hours urine protein quantitation,volume size of two kidneys and cortical thickness.ect.The prevalence of DKD in the four groups were counted respectively and the epidemic characteristics of the age,gender,family history of diabetic kidney disease,duration of diabetes,hypertension,Abnormal lipid metabolism,obesity,and hyperuricemia.etc were described.Risk factors for diabetic kidney diaease were analyzed by binary logistic regression.Results:1.The prevalence of DKD in T2 DM patients in our hospital was 50.5%,The highest proportion is the early DKD(26%),when refered to Mogensen staging,Followed by the clinical DKD(19.6%),the end-stage DKD was the least(4.9%).while the highest proportion was CKD1(19.1%)when refered to K/DOQI CKD staging;2.There were no obvious characteristics for the distribute of DKD in sex(χ2(df=1)is 1.159,P>0.05)and Body Mass Index(χ2(df=2)is 0.261,P>0.05).The prevalence of DKD increased with the growth of age(χ2(df=4)is 23.724,P<0.05).DKD patients Mainly concentrated in population which were over 71 years old(57.8%),and the prevalence of progressing into end-stage renal DKD increased with the age.The distribution of DKD was otherness in different ethnic(χ2(df=9)is 19.562,P<0.05),which distributed the most in Tibetan(56.8%),while the end-stage DKD were more likely to occurred in Hui people(8.7%),The increase of duration of diabetes(χ2(df=1)is 11.401,P<0.05)and DKD family history(χ2(df=1)is 8.376,P<0.05),poor blood glucose control(χ2(df=6)is 15.314,P<0.05)were associated with the increased prevalence of DKD.Patients with duration of diabetes >10 years(8.2%),DKD family history(8%),and glycosylated hemoglobin >8%(5.6%)were more likely to progress to the end of DKD;3.There were no signif icant differences for the distribution of DKD in patients with hypertension(χ2(df=1)is0.544,P>0.05)and hyperuricemia(χ2(df=1)is0.03,P>0.05)compared with the control group,When the type 2 diabetic patients with abnormal lipid metabolism(χ2(df=1)is 4.851,P<0.05)formation of carotid plaque(χ2(df=3)is 9.470 P<0.05)and hypothyroidism(χ2(df=1)is 12.771,P<0.05)the prevalence of DKD was significantly higher than the control group and the differences was of statistical significance.4.Multivar iate logistic regression analysis showed that age(OR=1.009,95%CI(1.003,1.014)),duration of diabetes(OR=1.183,95%CI(1.045,1.338)),family history of DKD(OR=0.796,95%CI(0.642,0.986)),abnormal lipid metabolism(OR=1.155,95%CI(1.023,1.305))and hypothyroidism(OR=1.219,95%CI(1.070,1.387))were risk factors for the progress of DKD.Conclusion: 1)The prevalence of DKD in T2 DM patients in our hospital was 50.5%,Early DKD accounted for the highest proportion of 26%.2)There were no significant differences for the distribution of DKD in gender,BMI,hypertension And hyperuricemia.but signif icant differences in ethnic,age,duration of diabetes,family history of DKD,and blood glucose control abnormal lipid metabolism and carotid atherosclerotic-plaque formation,abnormal thyroid function.3)Age,duration of diabetes,family history of DKD,patients with abnormal lipid metabolism,hypothyroidism were risk factors for the progress of DKD. |
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