Effects Of Tripterygium Glycosides On In-stent Restenoss And MACE Rate In Patients With Coronary Heart Disease After Percutaneous Coronary Intervention

Objective:To discuss the effect of tripterygium glycosides for stent restenosis in coronary heart disease patient and long-term prognosis.Methods: Divided the patients who hospitalized in Qingdao university affiliated hospital and People’s hospital of Gaomi from 2015.06 to 2015.12 with coronary heart disease(CHD)and accept the therapy of percutaneous coronary intervention(PCI)randomly into two groups,among age of 30 to 89.There were 53 cases of male and 21 cases of female in control group.All the patients had been offerred dual-antiplatelet drugs,statins after PCI.At the same time,the observation group contains 61 cases of male,18 cases of female.Apart from the same treatment of the control group,the observation group members takedtripterygium glycosides for 6 months.Collected and analyzed general data of all cases including triglyceride(tg),low density lipoprotein(LDL),total cholesterol(tcho),glycosylated hemoglobin(hba1c),ejection fraction(EF),systolic blood pressure(HBP),diastolic blood pressure(DBP),pulse(p).Keep follow-up visit for one year,checked the result of major adverse cardiac events(MACE)in patients(Death,nonfatal myocardial infarction,and target vessel reascularization).Applying COX multi-factor analysis and comparison of observation group and control group in the correction of the other variable incidence of MACE whether there was a statistically significant difference.Results: Among the observation group,6 cases showed gastrointestinal discomfort,3 cases showed WBC decrease,9 cases showed ALT increas after 2 months of taking Tripterygium wilfordii tablets.These symptoms inproved after reduced the dose or stopped the drug.The analysis results showed no statistically significant difference in age,sex,heart rate,triglycerides,blood pressure,left ventricular ejection fraction,lesion area and lesion types reference diameter,blood vessels between two groups of patients(P >0.05).The total cholesterol,low-density lipoprotein cholesterol(ldl-c),glutamic-pyruvic transaminase showed significant difference(P < 0.05),but the difference disappeared in 1years.Among the two groups of 153 patients,there were 15 cases with MACE incident.The MACE events rate was 9.80%,in which 3 cases in observation group,12 cases in thecontrol group.The total cholesterol,low-density lipoprotein cholesterol(ldl-c),glutamic-pyruvic transaminase showed significant difference(P < 0.05).Conclusion: 1.The use of tripterygium glycosides in the short term will reduce the patient’s white blood cells,increase the alanine aminotransferase,the effect disappeared after stopped the drug.2.Tripterygium wilfordii glycosides reduced the incidence of postoperative MACE events in PCI patients.3.Tripterygium wilfordii glycosides reduced the incidence of restenosis in PCI patients,but there was no statistically significantdifference between the two groups.