Evaluation Of The Cardiac Function In Patients With Breast Cancer Before And After Receiving Anthracycline By Three-dimensional Speckle Tracking Imaging

Objective To probe the clinical value of three-dimensional speckle tracking echocardiography in evaluating the early ventricular myocardial dysfunction in breast cancer patients treated with anthracycline.Methods A group of 40 breast cancer postoperative patients were received a epirubicin-based chemotherapy,whose basic health have no problem before chemotherapy such as conventional echocardiography、electrocardiogram et al.Conventional and 3D dynamic echocardiography were measured before chemotherapy and 2 cycles and 4 cycles after chemotherapy during 24 hours,and to compare the change of the parameters in the before and after.Results There are no difference in those conventional parameters such as LVESV、LVEDV、LVEF、LVFS、RVD、TAPSE、S’、RVFAC et al.Left ventricular global area strain(LVGAS)、left ventricular global longitudinal strain(LVGLS)and right ventricular global longitudinal strain(RVGLS)、right ventricular global circular strain(RVGCS)、right ventricular global radial strain(RVGRS)were significantly lower than the before,and negatively correlated to cumulative anthracycline dose,in which the area under the ROC curve LVGAS was 0.897,P = 0.000,-30.55% selected for the diagnosis cut-off point,a sensitivity of 0.857,specificity of 0.917;some of right ventricular strain parameters were earlier than the left.Conclusions 3D-STI is useful to find the early left and right ventricular myocardial dysfunction in breast cancer patients treated with anthracycline and early access the subclinical cardiactoxicity,and right ventricular may be earlier than the left,which can provide diagnosis basis to intervene timely for the clinical.