| Objectives:In recent years,which is the prevalence of the disease gradually riseing,with the increase of the number of diabetes and diabetic peripheral neuropathy screening advances,the treatment of diabetic peripheral neuropathy was Followed,Its methods include various neurotrophic factors,inositol,ganglion glucoside ester and linolenic acid,methyl cobalt amine,prostaglandin E1,bei front row element sodium and gabapentin,Although drugs varied,each have insufficient,For DPN patients safe,effective and inexpensive treatment is their best choice,Oxidative stress theory for DPN,ALA is now widely recognized one of antioxidants,But the effect is not ideal for some DPN patients and its treatment cycle is long,The IPC for physical therapy,Inflating the IPC’s six-section sleeve by inflating and rhythmically inflating the IPC,The stimulation of its large area of extrusion can reach deep blood vessels,lymphatics and muscles,And then gradually let go,Form a cycle of intermittent pressure for non-dead angles of tissue and limb,To promote the flow of blood from the far heart to the near heart,Finally,the function of improving circulation,preventing blood clotting and increasing the amount of blood oxygen in the nerve repair etc.Because high safety and good curative effect.Widely used in various fields in our country,In addition,The application time of patients with DPN is shorter,the efficacy and safety of DPN still need large sample of clinical studies and clinical trials,In view of this,this study based on oxidative stress and blood circulation theory,using the existing research results,on the premise of fully consider treatment principle for the patients with DPN treated by ALA in combination with IPC,observing its for type 2 diabetes to treat the clinical curative effect and safety of peripheral nerve,providing clinical evidence-based basis for alleiating DPN.Methods:From February 2015 to February 2017,100 patients with T2 DM combined DPN that hospitalized in Yanan dongguan branch comprehensive medical university affiliated hospital bringed into the research object.using the random number table method is divided into the treatment group(n = 50)and control group(n = 50):recording all patients clinical situations.into the group of all patients were given diet,exercise,Intensive Lifestyle Intervention,guided blood glucose monitoring and self management ability.and hypoglycemic measures to control blood sugar.meanwhile Combined with dyslipidemia,given atorvastatin calcium treatment;Combined with hypertension,Lowered blood pressure treatment,choosing ACEI class or ARB class or 2Ca+channel blockers.Treatment group would combined ALA injection 600 mg with 0.9% Na Cl injection 250 ml avoiding light static drop after compatibility of 250 ml,once a day,use 2 weeks in a row,at the same time combined the IPC,20 minutes each time,twice a day;Control group only would combined ALA injection 600 mg with 0.9% Na Cl injection 250 ml to avoid light in static drop,once a day,consistent with the treatment group therapy.Comparing the two groups before treatment and after treatment nerve self-conscious symptom scores(TSS),motor nerve conduction velocity(MNCV),sensory nerve conduction velocity(SNCV)and amplitude(AMP)to improve the situation.All the data with SPSS20.0 software for statistical analysis.Result:1.General clinical data between the two groups(age,gender,FBG,Hb Alc,BMI,Hcy,UA,RDW-CV,AST,TG,LDL-C,TC,hdl-c leel,drinking age,average consumption/month,DPN course,DM course,pulse pressure,smoking,smoking/day,concurrent PAD(with/without),concurrent DR(Ⅰ/Ⅱ/Ⅲ/Ⅳ)),the relative change than no difference in statistics(P > 0.05),concurrent DN(Ⅲ G1 / G2 / G3a/G3b/Ⅳ G4)changes in the relative than there are differences in statistics.2.Between groups treatment 2 weeks ago in patients with burning,numbness,tingling,cutting pain score and total scores of TSS,dropped significantly,The differences ave statistical meaning(P<0.01),2 weeks after treatment,the comparison between the two groups,patients of numbness,like pain,burning in the TSS scores were obviously decreaser,the differences have statistical meaning,Excepting cutting pain(P>0.05).3.Compared to before treatment,the MNCV and SNCV of the treatment group and control group after treatment had unconspicuously changed,the difference have statistically insignificant(P>0.05).Two groups amplitude after treatment motor nerve tibial distal and proximal,sural total nerve distal and proximal,sensory nerve of the ulnar nerve,median nerve and sural nerve higher before the treatment,the differences have statistical meaning(P<0.01),Excepting the median nerve distal and proximal.Compared with control group,sural nerve and tibial nerve proximal and distal,sural total nerve proximal and distal amplitude were significantly increased,the differences have statistical meaning(P<0.05),Excepting the Median nerve,ulnar nerve.4.After 2 weeks after treatment,the treatment total effective rate of patients with the control group and treatment group were 67.3% and 87.5% respectively.comparing the two groups,the treatment group is higher than the control group,the differences have statistical meaning(P < 0.05).5.In the second group of patients in addition to a case of a 70-year-old male patient in the process of static drops of ALA fourth day appeared dizziness,the whole body skin redness,itching,see red macula and two due to occupy the field of study,a total of 97 patients completed treatment.Excepting thereatment group,the patients with a 73-year-old male treatment 3 days after lower limb pain,heavy feeling,the symptom is reduced to reduce the air pressure wave after,completed research.during the study were more than patients without malignant,rashes,bosom frowsty,lower limb pain stars such as self-conscious symptom.Because of too few adverse reactions,it can’t statistics of the difference of adverse reactions between the two groups.Conclusion:1.Alpha lipoic acid(ALA)joint intermittent pneumatic compression(IPC)relative to the ALA can make the patients with diabetic peripheral neuropathy(DPN)nerve self-conscious symptom scores significantly lower(TSS),sural nerve and tibial nerve proximal and distal,sural total nerve proximal and distal amplitude(AMP)were significantly elevated,Curative effect is superior to the single drug treatment.2.Alpha lipoic acid(ALA)joint intermittent pneumatic compression(IPC)relative to the ALA treatment of diabetic peripheral neuropathy(DPN),does not appear hemorrhage,infection and lower limb pain adverse reactions,prompting the IPC for DPN patients is safe and effective,therefore,it can regularly joint IPC treatment in the process of the treatment of DPN,to improve the curative effect,to increase patient compliance,to shorten significantly the length of hospital stay. |
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