| Objective Patients with ST-segment elevation myocardial infarction were enrolled in this study.Patients with percutaneous coronary intervention(PCI)who underwent percutaneous coronary intervention(PCI)were treated with Shengmai Injection.(LVEF),left ventricular end diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVESD),left ventricular end-diastolic diameter(CK-MB),cardiac troponin(c TNI),changes in cardiac function,major cardiovascular events(MACE),and the effects of ST-segmentation Elevated acute myocardial infarction in patients after the application of Shengmai injection and to give emergency PCI after myocardial tissue levels of microcirculation and cardiac function improvement.Methods A total of patients with acute ST-elevation myocardial infarction(AMI)in the emergency department of Yanzhou District People’s Hospital of Jining City,Shandong Province,from December 2015 to December 2016 were enrolled in this study.Fifty patients were randomly selected as the total clinical trial.According to the experimental criteria,50 patients were included in the observation group and 25 patients in the control group.The control group selected 25 patients,immediately after admission to open the intravenous access,oxygen,intensive care,ECG monitoring,oxygen saturation monitoring,given oral aspirin enteric-coated tablets 300 mg,clopidogrel tablets 600 mg,subcutaneous injection of low molecular weight calcium calcium 5000 iu,with family members to actively communicate the condition,inform patients and their families of emergency PCI surgery and the need for surgical risk,patients and their families agreed to emergency PCI surgery,and the signing of emergency PCI surgical treatment After the consent of the patients before the acute myocardial infarction in patients with emergency coronary intervention,intraoperative and postoperative according to the patient’s "offender" coronary artery thrombosis load platelet glycoprotein Ⅱ b / Ⅲ a receptor antagonist: tirofi Class anti-thrombosis application,after surgery to be conventional anti-platelet aggregation,anticoagulation,moderate infusion therapy.In the observation group,25 patients with acute ST-segment elevation myocardial infarction were treated with Shengmai injection(Jiangsu Suzhong Pharmaceutical,10 ml / branch)60ml +glucose or(diabetic)saline injection Liquid 250 ml into the liquid intravenous infusion once a day,7 days for a course of treatment,patients and patients with surgery agreed to sign the emergency treatment of PCI surgery informed consent to be percutaneous coronary intervention,intraoperative and postoperative basis Patients with "offenders" of coronary arterial thrombosis load given platelet glycoprotein IIb / IIIa receptor antagonist:intravenous infusion of tirofiban for antithrombotic therapy,after surgery to give general antiplatelet,anticoagulation,moderate infusion treatment The Record the general condition of the patient,such as the gender,age,heart rate,blood pressure,history of hypertension,history of diabetes and history of smoking,and observe and record the patient’s plasma before and after treatment(LVVE),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),ECG ST-segment descent amplitude,left ventricular end-diastolic diameter(LVEDD),left ventricular end-diastolic diameter Cardiac cardiac kinase isoenzyme(CK-MB),cardiac troponin(c TNI),cardiac function grade,and major cardiovascular events.Apply the SPSS22.0 software package to the various observation parameters listed above and analyze the statistical data on the computer.Results There was no significant difference in sex,age,heart rate,blood pressure,hypertension,diabetes history,smoking history,cardiac function(Killip grade)and myocardial infarction in the observation group and the control group(p> 0.05),Indicating that between the two groups are comparable.(LVESD),left ventricular end diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)after left ventricular ejection fraction(LVEF),left ventricular endocytosis(P <0.05).The difference between the observation group and the control group was statistically significant,indicating that the application of Shengmai injection could improve the cardiac remodeling and radiotherapy of the postoperative patients,and there was no significant difference between the two groups Blood function.The results of ST segment depression in ECG suggest that there is no significant difference between the two groups after 2h,24 h and 7d,but the difference is not statistically significant(P> 0.05),limited to less sample size,The application of injection can improve the microcirculation perfusion of myocardium after PCI.4,CK-MB,c Tn I and plasma amino-terminal B-type brain Brain sodium peptide precursor(NT-pro BNP)parameters of the study found that the observation group and the control group before treatment CK-MB,c Tn I and plasma amino-B(P> 0.05).After treatment,the parameters were significantly lower than those before treatment,especially in the observation group(P <0.05),and the observed group was significantly higher than that in the control group(P <0.05)The difference between the control group and the control group was statistically significant(P <0.05).The observation group and the control group for the classification of cardiac function,the observation group in the treatment after 3 months compared with the control group had a statistically significant difference(P <0.05),suggesting that the application of Shengmai injection can improve the patient after PCI Heart function.6,the incidence of cardiovascular events in the main indicators(including cardiac arrest,non-fatal myocardial infarction,acute cardiac dysfunction,re-PCI)contrast,the control group the incidence of cardiovascular events were significantly more than the observation group,The difference was statistically significant(P <0.05).Conclusions For acute ST-segment elevation myocardial infarction and emergency patients after PCI,the use of Shengmai injection can effectively improve the function of myocardial injury after PCI and myocardial microcirculation,reduce reperfusion injury Of the strength,enhance cardiac function,improve the occurrence of poor prognosis,worthy of clinical practice in the application of treatment. |
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