Study On The Correlation Between E2 Level And Fg In Postmenopausal Women

With the development of society and the improvement of people’s living standard,the cardiovascular disease has been increasing year by year.It has become a common and frequently occurring disease and a hazard to human health.More and more risk factors lead to patients with high risk,these risk factors include age,gender,smoking history,hypertension,diabetes,high blood LDL-C etc,and the coexistence of multiple risk factors will make the risk of cardiovascular disease increased significantly.Some interventions to control risk factors can effectively prevent the occurrence and development of cardiovascular disease.At present,the incidence of cardiovascular disease in women is increasing.Women with cardiovascular disease are characterized by atypical symptoms and diversified performance.Its pathogenesis is not yet clear,it is believed that a variety of mechanisms involved in its occurrence and development.Risk factors such as age,history of hypertension,history of diabetes,history of hyperlipidemia play an important role,but these traditional risk factors can not fully explain the occurrence and development of cardiovascular disease in women.The new risk factors,such as the level of estradiol(estradiol,E2),and the level of fibrinogen(fibrinogen,Fg),have attracted more and more attention.Previous studies have shown that the incidence of cardiovascular disease in women is lower than that of men,and the onset time is later than that of men.The new risk factors,such as estrogen levels,are becoming more and more important.Estrogen is a fat soluble steroid hormone,there is only a small amount of estrogen secretion before puberty,and a large increase in the secretion after puberty.After menopause,due to the decline of ovarian function,the synthesis and secretion of sex hormone levels decreased,and thelevel of estrogen decreased.The epidemiological study found that the incidence of cardiovascular disease in postmenopausal women increased,short-term can achieve the similar levels of male,results suggest that estrogen is not only a sex hormone,it may be related to the incidence of cardiovascular events in women.The pathogenesis of cardiovascular disease is mainly determined by three factors,such as the change of blood vessel wall,abnormal blood components and abnormal blood flow.The increase of plasma Fg level can cause the change of blood rheology,increase the blood viscosity,promote the aggregation of platelet and red blood cells,and cause the thrombosis.The American Heart Association(AHA)guidelines for prevention of coronary heart disease in women in 2007 clearly pointed out that the new risk factors of fibrinogen for coronary heart disease in women.A large number of studies have shown that fibrinogen is a risk factor for cardiovascular disease.Fg concentration was affected by the level of E2.Studies have shown that concentration was affected by the level of E2.Studies have shown that estrogen can play a role in the protection of cardiovascular disease by reducing the level of fibrinogen.Objective: The purpose of this study was to further clarify the correlation between E2 level and Fg in postmenopausal women,In order to provide reference for clinical diagnosis and treatment of female patients with cardiovascular disease.Methods:One hundred and twenty-seven postmenopausal women were enrolled in this clinical trial,who were selected from the inpatients of the Hebei General Hospital Heart Center from April 2016 to October2016.According to age,they were divided into control group(group Ⅰ,less than 65 years of age)in 58 cases,the experimental group(Group II,more than65 years of age)in 69 cases.E2,Fg,APTT,TT,PT were measured respectively in the two groups.Other factors that may affect the experiment results,including: coronary heart disease,hypertension,diabetes,menopausal age.The data were collected and analyzed by statistical methods.Results:1 Comparison of basic clinical characteristics between group I and group IIThe clinical data of all the participants were collected,and the clinical characteristics of the patients were statistically analyzed.We found that there was no significant difference between the two groups in menopausal age,coronary heart disease,hypertension and diabetes prevalence between group I and group II(P > 0.05);2 Comparison of E2,TT,PT,APTT and Fg levels in group I and group IIBy collecting blood samples from all participants,we measured their E2,TT,PT,APTT and Fg levels.Compared with group I,we found that in group II the E2 level was significantly lower,the Fg level was significantly increased,the TT was shortened,the difference was statistically significant in the two groups(P<0.05).There was no significant difference in PT and APTT between the two groups(P > 0.05);3 Study on the correlation between E2 level and PT,APTT,TT,Fg in all selected objects.Through the Pearson correlation analysis of the data,we found that the level of E2 was significantly correlated with Fg,and was negatively correlated(r =-0.466,P < 0.05);There was a positive correlation between E2 level and PT(r 0.026,P < 0.05);By detecting the correlation between E2 level and APTT,TT,we found no correlation(P > 0.05).Conclusion:1 With the age increasing in postmenopausal women,the level of E2 was decreased,the level of Fg was increased and the TT was shortened.2 The incidence of cardiovascular disease in postmenopausal women may be related to the decrease of E2 level.E2 may affect the development of cardiovascular disease by regulating the degradation of Fg in female.