The Relationship Between The Levels Of Estrogen And Coronary Microvascular Disease In The Postmenopausal Women

Objective: To observe the levels of estrogen in postmenopausal women,and to analyze the relationship between the estrogen levels and occurrence of coronary microvascular disease(CMVD).Methods: The postmenopausal patients(n=40)with the past symptoms of angina pectoris from the fifth department of cardiology in the second hospital of Hebei medical university from December 2015 to February 2017 were enrolled in this study,who were excluded obstructive coronary artery disease by coronary angiography,and they were divided into two groups as the experimental group(group A)and the control group(group B)according to the results of Singe photon emission computed tomography(SPECT).A total of 22 cases aged from 51 to 65 years were in Group A,and the average age was 56.82±3.42 year-old.A total of 18 cases aged form 52 to 65 years were in Group B,and the average age was 57.11±3.86 year-old.The levels of estrogen were compared between group A and B,and the correlation analysis between the estrogen levels and CMVD were made.The history,blood pressure,heart rate and routine analysis of blood,myocardial enzyme,cardiac troponin I(cTnI),renal function,electrolyte and thrombolytic therapy monitoring,liver function,blood lipid,blood glucose,sex hormone,hsCRP and so on were recorded in all the patients.A Doppler echocardiography was performed for measuring the cardiac function in all the patients.All the patients were accepted the same conventional treatment.All the blood samples were tested in the clinical laboratory of the second hospital of Hebei medical university and the Doppler echocardiography was done in the ultrasonic department of the second hospital of Hebei medical university.Coronary angiography were done in the catheterization room and SPECT were done in the Nuclear Medicine Department of the second hospital of Hebeimedical university.All the data were analyzed with SPSS21.0 software.A P-value of less than 0.05 is considered as statistical significance.Results:1 The comparisons of the basic situation between group A and group B:There were no significant differences between group A and B in baseline clinical characteristics(P>0.05),including the age,menopausal time,body mass index(BMI),heart rate,hypertension history,diabetes history,levels of blood lipoids and glucose.There were significant difference between group A and group B in hsCRP(1.45±0.64vs0.87±0.42,P=0.002).The systolic blood pressure in group A was lower than that in group B(125±18vs139±15,P=0.012).The diastolic blood pressure in group A was lower than that in group B(76±11vs83±10,P=0.032).2 The comparisons of the levels of sex hormone between group A and group B: There were no significant differences between group A and B in sex hormone(P>0.05),including follicle stimulating horm(FSH),progesterone,testosterone,and luteinizing hormone(LH).The levels of estrogen in group A was lower than that in group B(18.41±8.52vs38.56±10.38,P=0.000).3 The binary logistic regression analysis displayed that the hsCRP was the independent risk factors and the levels of estrogen was the independent protective factor.The value of hsCRP was 10.957,the P value was 0.029,and the value of the estrogen levels was 0.731,the P value was 0.004,which were statistical significance.Conclusion:1 The level of estrogen was a protective factor of CMVD in postmenopausal women,and the higher the blood estrogen level,the lower the possibility of CMVD in postmenopausal women.2 The hsCRP was an independent risk factor for CMVD in postmenopausal women,and the higher the hsCRP level,the higher the possibility of CMVD in postmenopausal women.