Nitric Oxidex Inhalation For Treating Adult And Child Acute Respiratory Distress Syndrome Complications:A Meta Analysis

Objective :To conduct a meta analysis on the intric oxide(iNO)inhalation for treating adult and child acute respiratory distress syndrome(ARDS)complications in order to provide reference for its clinical application.Methods:The published Chinese and English literatures on iNO inhalation for treating ARDS were searched by computer retrieval.With the occurrence rate of renal function injury,intracranial hemorrhage or periventricular leucomalacia(PVL),retinopathy of prematurity,cerebral palsy,etc.as the observation indicators of end point efficacy,the odds ratio(OR)of merged curative effect and 95% confidence interval(95%CI)were obtained.Then the qualitative and quantitative comprehensive evaluation was performed.The qualified literatures were evaluated by the inclusion and exclusion standards.Results:The renal function injury: the cases number in the iNO treatment group was higher than that in the control group,the difference was statistically significant(93 cases VS 53 cases,P<0.05);intracranial hemorrhage or PVL: the difference between the iNO treatment group and the control group had no statistical significance(26 cases VS 39 cases,P>0.05);nerve injury(cerebral palsy): the iNO treatment group was lower than the control group without statistical difference(6 cases VS 9 cases,P>0.05);retinopathy: the iNO treatment group was lower than the control group without statistical difference(9 cases VS 13 cases,P>0.05).Conclusion:iNO for treating adult ARDS could increase the risk of renal impairment,therefore the use of iNO for treating ARDS adult patients with renal impairment is not recommended.