88 Cases Of Specific Pathogens Of Infantile Purulent Meningitis Clinical Analysis

Objective: To explore the purulent meningitis different pathogenic difference,antibiotics curative effect,laboratory/imaging examination and prognosis,to provide basis for clinical treatment.Methods:Our hospital in January 2008-December 2015,88 cases clear pathogeny PM of children with datum of cases were retrospectively analyzed.Results:(1)There are differences with different pathogens in age;length of hospital stay;white blood cell of peripheral blood,neutral grain percentage,platelet count;pan method of cerebrospinal,nucleated cell count,glucose and protein content;early combined hydrocephalus/subdural effusion.And the early combined hydrocephalus/subdural effusion is associated with hospitalization prolonged(P = 0.000).(2)This research shows that the death rate 28.3%,the incidence of complications was 30.3%.(3)Bacterial drug resistance: Streptococcus pneumoniae and staphylococcus genus are no drug resistance to vancomycin,penicillin resistant rate is 94% and 77%,respectively.E.Coli: no drug resistance to meropenem/imipenem,the resistant to cefotaxime is 68%,to cefepime is 50%.gram-negative bacillus only without resistance to moxifloxacin,the resistant rate to meropenem/imipenem is 30%.(4)Both single factor and multiple factors analysis shows that the prognosis is associated with procalcitonin,Cranial imaging abnormalities(P =0.005,0.01,respectively),Nothing with age,convulsions,consciousness,head MRI and EEG abnormalities.Conclusion:(1)There exist certain differences in peripheral blood and cerebrospinal fluid examination of different pathogenic bacteria of PM.(2)Bacterial resistance is apparent,the fatality and sequelae rate is high.(3)The early combined hydrocephalus/subdural effusion is associated with hospitalization prolonged.The prognosis is associated with procalcitonin and extensive cerebral edema/hydrocephalus/subdural effusion.