Diagnostic Value Of Prospective Electrocardiographgated Of CT To Congenital Heart Diseases: A Meta-analysis

Objective: Perform a meta-analysis to evaluate the clinical diagnostic value of prospective electrocardiograph(ECG)gated of CT cardiac angiography in congenital heart diseases of Chinese population.Methods: The relevant literatures by searched to study CT prospective ECG-gated in diagnosis of congenital heart disease in domestic and foreign.Data were extracted and heterogeneity test was performed by Meta-disc1.4 software,and different effect models were selected according to the heterogeneity.Meanwhile,using this soft to calculated the sensitivity(SEN),specificity(SPE),likelihood ratio(LR)and its 95% confidence interval(CI),respectively.Rendering the forest maps and summary receiver operator characteristic curve(SROC).In addition,the area under curve(AUC)would be evaluated.The study quality was assessed by the Quality Assessment for Diagnostic Accuracy Studies(QUADAS)and the data extraction were performed.Results: 12 articles were included.with a total of 1431 congenital heart defects.CT prospective ECG-gated technique has no heterogeneity in the sensitivity and specificity of congenital heart disease.The total sensitivity,the total specificity,positive LR、negative LR and its 95% confidence intervals of CT cardiac angiography were 0.96(95%CI:0.94~0.97),1.00(95%CI:1.00~1.00),365.94(95%CI:231.18~579.26),0.04(95%CI:0.03~0.05)with fixed effect model,respectively.The area under the SROC curve is 99.86%,Q* was 0.9879.Conclusions: Prospective ECG gated CT is higher for the diagnosis of congenital heart disease sensitivity and specificity,at the same time,under the receiver operating characteristic curve area is large,for congenital heart disease with high and stable diagnostic performance.