Clinical And Pathological Analysis Of Idiopathic Membranous Nephropathy

Objective: This is a retrospective analysis of patients with pathological diagnosis of idiopathic membranous nephropathy in Quanzhou city during the past 3 years.It involves the clinical manifestations,the pathological findings and auxiliary examination results of these patients.The order is to summarize the general characteristics of the epidemiology,the clinical and pathological characters,and the relationships among them.Methods: A single center retrospective analysis was carried out in Quanzhou city from January the 1st,2013,to June the 30 th,2016.62 patients were diagnosed idiopathic membranous nephropathy after the renal biopsy.A few of statistical methods were carried about to analyze the relationship among the epidemiological,clinical and pathological characters.Results: There were 35 male and 27 female of the 62 patients.The number of the male was a little more than that of the female.Their ages were ranged from 20 to 75 years old,with an average of 47±13.17.Most of them were the youth or the middle ages.The youth accounted for 42% of the 62 patients,while the middle ages accounted for 40%.There were significant differences of the serum creatinine,urea nitrogen,uric acid and body weight between male and female,but no difference of the ages between them.The male patients had higher medians of the serum creatinine,urea nitrogen,uric acid and body weight than the female patients had(P<0.05).Patients of the elder group had higher blood urea nitrogen levels than those of the other groups had.When compared with the young group,the middle aged group had a lower level of the total cholesterol,while the elder group had a higher level of it.Patients in phase two and phase threeof the membranous nephropathy were older than patients in phase one when them accepted the renal biopsy(P<0.05).The blood pressure increased with the pathological stage.Patients in phase three had an average systolic blood pressure level of 130 mm Hg,which was higher than patients in the other phases.Conclusion: For patients with idiopathic membranous nephropathy,male and the elder had the severe clinical manifestations.Most of the patients were in phase two according to the pathology.And the clinical features were not completely corresponding to the pathology.Objective: To investigate the role of serum PLA2 R antibody in the diagnosis and monitoring of idiopathic membranous nephropathy.Methods: This was a retrospective analysis of the serum PLA2 R antibodies and related clinical data of patients with idiopathic membranous nephropathy in our hospital and the First Hospital of Quanzhou since January the 1st.2016 till now.There were 16 patients who were involved in this study.They were collected with the venous blood sample in the morning of the day that they accepted the renal biopsy.The serum PLA2 R antibody was detected by ELISA method.SPSS 18.0 was used to analyze the differences of clinical characteristics between PLA2 R positive patients and negative ones.Results: Among the 16 patients with idiopathic membranous nephropathy,8cases were with the serum PLA2 R antibody positive(50%),and the other 8 were negative(50%).There might be statistical differences in the course of disease before the renal biopsy between the serum PLA2 R antibody positive patients and negative ones(positive: 29.19±46.90;negative patients: 1.22±0.80,P<0.05).And there might also be statistical differences in the hematuria(positive: 35.41 ± 50.23;negative patients: 1691.75 ± 3066.75,P < 0.05).The average hematuria of the positive group was significantly lower than that of the negative one.Although the difference of the average blood pressure between the positive and the negative was noticed according to the figures(positive: 35.41±50.23;negative patients: 1691.75±3066.75,P<0.05).There was no statistically difference in fact according to the further analysis.The blood pressure might not affect the positive rate of serum PLA2 R antibody,as it was 50% of the rate both in the high blood pressure group and the normal one.Conclusion: There might be statistical differences in two aspects,separately the course of disease(month)and the hematuria(x 106/L),between serum PLA2R antibody positive patients and negative ones.It still needs to be further verified that whether the blood pressure will affect the level of serum PLA2 R antibody.