The Research Of TF~+MPs Level In Plasma Level Of Patient With Chronic Mountain Sickness

Objective : By measuring CMS patients’ and xx healthy citizens’ Plasma level of Tissue Factor-Positive Microparticles(TF+MPs),to investigate the role of TF+MP in the hypercoagulable state of CMS patients,and to provide a basis for the mechanism of CMS hypercoagulable state.Methods:Employ enzyme-linked immunosorbent assay(ELISA)to assess plasma level of TF+MPs in two sampling groups.Respectively:21 CMS patients,21 healthy xx citizens.Results:CMS patients’ plasma level of TF+MPs(68.24±33.25)pg/ml was higher than the level of controls(44.28±25.22)pg/ml(P < 0.05);CMS patients’ level of PLT(116.33±32.21)×109/L(P<0.05)was lower than the level of controls’(189.76±44.18)×109/L(P < 0.05);CMS patients’ APTT(40.04±9.70)S was longer than contrls’(31.85±4.93)S(P<0.05);CMS patients’ PT(17.55±4.34)S was longer than contrls’(31.85±4.93)S(P<0.05);CMS patients’ D-dimer(2.00±0.99)mg/L was higher than the level of contrls’(0.55±0.17)mg/L(P<0.05);CMS patients’ FDP(2.40±0.84)mg/L was higher than controls’(1.26±0.27)mg/L(P<0.05);CMS patients’ FIB(3.13±0.52)g/L was higher than controls’(2.65±0.38)g/L(P<0.05);CMS patients’ TF+MPs and FIB was positively crrelated(r =0.435).Conclusion : The plasma level of TF+MP in CMS patients was higher than that controls,suggesting that TF+MPs may play a role in the hypercoagulable state of CMS patients.The level of platelet CMS patients is lower than that of cntrols,which may be hypoxia caused vascular endothelial injury,platelet activation,plasma TF+MPs increase.thereby It increasing hypercoagulable state of the CMS patients and micro thrombus formation,which result in platelet consumption and peripheral blood platelet decrease.CMS patients’ TF+MPs and FIB shows positive crrelation.