The Effect Of Nonalcoholic Fatty Liver Disease On The Severity Of Acute Pancreatitis

ObjectiveTo investigate the relationship between nonalcoholic fatty liver disease and the severity of acute pancreatitis,we collected the data of hospitalized patients with acute pancreatitis so as to provide scientific basis for the diagnosis,treatment,prevention and prognosis of acute pancreatitis.MethodsAll of the 637 patients with acute pancreatitis from June 2013 to September 2016 were enrolled in this study.According to the inclusion and exclusion criteria,251 cases were included in our study,among which 144 cases were male(57.4%)and 107 cases were female(42.6%).SPSS22.0 software was used to analyze all of the data including general items,blood indexes and supplementary examination results.Mann-Whitney U test(in case of non-normal distribution)or T test(in case of normal distribution)was used to compare data between two groups.Chi-square test was used to assess differences in categorical variables,nonparametric test of multiple independent samples was used for the diversity comparison and the risk factors were analyzed by using logistic regression analysis.Excel 2003 and GraphPad Prism 6.0 software were utilized to plot charts.Results1.The severity of acute pancreatitis in patients with nonalcoholic fatty liver disease had a statistically significance with that of patients without nonalcoholic fatty liver disease,(χ2=11.004,P=0.001).And the severity of nonalcoholic fatty liver disease had a statistically significance with the severity ofacute pancreatitis(χ2=7.444,P=0.024).Nonalcoholic fatty liver disease(95%CI: 1.261-2.878,OR=2.478,P=0.017),white blood cell count(WBC)(95%CI: 1.747-7.043,OR=3.508,P=0.000)and amylase levels(95%CI: 1.148-3.868,OR=2.107,P=0.016)respectively had a correlation with the severity of acute pancreatitis(P<0.001).2.The body mass indexhad a statistically significance with the severity ofacute pancreatitis(χ2=13.082,P=0.004).There was a statistically significance in the severity of acute pancreatitis between patients with obesity and those without obesity(χ2=9.092,P=0.003).3.There was a positive correlation between the body mass index(BMI)and triglyceride(TG)in patients with acute pancreatitis complicated with nonalcoholic fatty liver disease(r=0.360,P=0.000).There was no correlation between BMI and fasting blood glucose,triglyceride and fasting blood glucose respectively(P> 0.05).Conclusion1.Nonalcoholic fatty liver disease was associated with the severity of acute pancreatitis.And the severity of nonalcoholic fatty liver disease had an effect on the mild acute pancreatitis,moderately severe acute pancreatitis and severe acute pancreatitis.2.Nonalcoholic fatty liver disease,white blood cell count(WBC)and amylase levels were the risk factors for the severity of acute pancreatitis.3.Body mass index was an indicator for the severity of acute pancreatitis.