Comparison Of The Efficacy And Safety Between Whole Brain Radiotherapy Combined With Targeted Drugs And Whole Brain Radiotherapy For Non Small Cell Lung Cancer With Brain Metastasis: A Meta Analysis

Purpose The effect of whole brain radiotherapy in patients with non-small cell lung cancer with brain metastasis was poor,In recent years,some studies have shown that the effect of whole brain radiotherapy combined with targeted therapy in patients with non-small cell lung cancer patients with brain metastases is significantly better than that of whole brain radiotherapy alone.But some studies have shown inconsistent results.To compare the efficacy and safety between whole brain radiotherapy(WBRT),combined with targeted therapy and WBRT alone in the treatment within non small cell lung cancer(NSCLC)with brain metastasis by Meta analysis.Methods A literature search was conducted among Pub Med,Embase,the Chinese National Knowledge Infrastructure databases and Wanfang which related WBRT plus target therapy or WBRT alone in the treatment of NSCLC with brain metastases from inception to May,2016.Studies quality was assessed by Newcastle-Ottawa Scale(NOS),odds ratios(OR)and 95% confidence intervals(CIs)as effect measures.The data analysis were performed using Rev Man5.2.Fifteen eligible studies including 1084 cases were included.Results Our study showed that compared with WBRT alone,WBRT combined with targeted therapy showed higher disease control rate(OR: 3.09,95% CI 2.11-4.54,P < 0.00001)and 1-year overall survival(OR: 2.55,95% CI 1.84-3.54,P<0.00001),differences were statistical significance.For the safety,add targeted therapy were frequently had rash(OR: 9.10,95% CI 2.89-28.66,P = 0.0002),but most of them were 1-2 grade toxicity and could be tolerated.Conclusion WBRT combine with target therapy is superior to WBRT alone and well tolerated in the treatment of NSCLC with brain metastases.In addition,more high quality randomized controlled trials are needed.