| Part 1 : The correlation of visceral adipose index levels and cardiovascular risk factors in patients with adult growth hormone deficiencyObjective: To examine the correlation of Visceral adipose index(VAI)evels with anthropometrics,glycolipid metabolism markers and high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)in patients with adult growth hormone deficiency(AGHD).Methods: A total of 40 AGHD patients from First Affiliated Hospital of Chongqing Medical University and 40 healthy adults from physical examination centre(control group)matched with age and gender were enrolled in this study.The general anthropometries and blood biochemical indexes were collected and compared between two groups.Waist circumference(WC),body mass index(BMI),waist-hip ratio(WHR),waist-height ratio(WHt R),and visceral adiposity index(VAI)were examined.,homeostasis model assessment-insulin resistance(HOMA-IR),homeostasis model assessment β-cell function(HOMA-β),LDL-C/HDL-C,TC/HDL-C,and TG/LDL-C were calculated of two groups.Results: 1.Compared with control group,body mass index(BMI),waist circumference(WC),waist-hip ratio(WHR),fasting insulin(FINS),HOMA-β,HOMA-IR,triglyceride(TG),LDL-C/HDL-C,TC/HDL-C,hs-CPR,IL-6,VAI were significant higher,but HDL-C levels were lower in AGHD group(P<0.05).2.There was a positive association between VAI and all the WC,WHR,FINS,HOMA-β,HOMA-IR,TC,LDL-C/HDL-C,TC/HDL-C,TG/LDL-C,hs CRP and IL-6(P<0.05).3.Multiple linear regression analysis revealed that hs-CRP and IL-6 were independent risk factors of VAI.VAI was most association with lipid metabolism and inflammatory cytokines among WC,BMI,WHR,WHt R and VAI analysed by Pearson correlation.Conclusion: VAI is significantly higher in AGHD patients than healthy people,and it shows a strong correlation with many risk factors for cardiovascular diseases.PART 2: Visceral adiposity index: a simple and accurate index for predicting metabolic syndrome in patients with adult growth hormone deficiencyObjective: To investigate the correlation of visceral adiposity index with metabolic syndrome in patients with adult growth hormone deficiency.Methods: Totally 66 patients with AGHD and 66 control subjects matched with the age and gender were enrolled.The general anthropometries and blood biochemical indexes were measured.body mass index,waist-hip ratio,HOMA-IR were calculated.Results: 1.Compared with those in control group,FINS,VAI,WC,WHR,TG and HOMA-IR were increased in AGHD group,while high density lipoprotein-cholesterol(HDL-C)level was lower in AGHD group(P<0.05).2.When visceral fat indexes were divided into low-index group,mid-index group and high-index group(respectively from 0.43 to 1.64,1.65 to 3.39 and 3.75 to 30 by using Tri-sectional quartile,there were statistical differences in morbidity and metabolic indexes among all groups.Weight,WC,HC,DBP,FINS,BMI,HOMA-IR and TG increased as VAI increased(P<0.05).3.In addition,the results of Person analysis showed that there was a significant association between visceral adiposity index and metabolic syndrome components in AGHD patients.4.ROC analysis showed that VAI was a significant discriminator for MS in AGHD patients,and the sensitivity is 96.0% while the specificity is 61%.Conclusion: Visceral adiposity indexes is significantly correlated to MS in AGHD patients,which can be a reliable diagnostic accuracy for MS in AGHD patients.PART 3:The association between Galectin-3 and insulin resistance in patients with adult growth hormone deficiencyObjective: To investigate the correlation between the galectin-3 and insulin resistance in AGHD).Methods: 96 patients with AGHD and 96 healthy subjects were collected.The anthropometric parameters and biochemical indexes of the two groups were measured.Serum galectin-3 levels were measured by enzyme-linked immunosorbent assay(ELISA).The body mass index(BMI),waist to hip ratio(WHR)and HOMA-IR were calculated.Results: 1.Compared with the control group,the levels of WHR,WC,FPG,FINS,HOMA-IR,TG and CRP in AGHD group were significantly higher than those in control group(P <0.05),HDL-C and Galectin-3 were significantly lower(P <0.05).There were no significant differences in age,sex,height,blood pressure and hip circumference between the two groups(P>0.05).2.The AGHD group was divided into insulin resistance group and non-insulin resistance group.The galectin-3 level in insulin resistance group was lower than that in non-insulin resistance group(P<0.05).The levels of WHR,WC,FPG,FINS,HOMA-IR,HOMA-? and TG in insulin resistance group were significantly higher than those in non-insulin resistance group,with the lower level of HDL-C.(P<0.05).There were no significant differences in age,sex,height,blood pressure,hip circumference and CRP between the two groups(P>0.05)3.AGHD were divided into group A,B,C,D according to Galectin-3 level.We find FINS and HOMA-IR were decreased with the increase of Galectin-3 level(P<0.01),and low levels of Galectin-3 were associated with insulin resistance.4.The results of Person analysis showed that there was a significant association between Galectin-3 and HOMA-IR,FINS,FPG,GH,IGF-1 in AGHD patients.5.The logistic regression analysis find Galectin-3 levels were significantly associated with insulin resistance(OR=0.160,95% CI=0.052-0.497,P <0.5).The prevalence of insulin resistance in group A,group B,group C and group D was 13,10,7,5,the prevalence rate was 54%,41%,29%,20%.Insulin resistance decrease while the rising of galectin-3 after adjusting age and gender.Conclusion: Galectin-3 levels in AGHD patients were significantly lower than those in healthy subjects and were associated with insulin resistance. |
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