Synthesis Of Vortioxetine And Study Of Copper Catalyzed Coupling

Vortioxetine was received its first approval for MDD by the US FDA in September 30,2013.MDD was also called depressive disorders,with significant and persistent low mood as the mai clinical features.It was the main types of mood disorders.Clinical shows low mood and disproportionate to the situation.Sullen mood of depression shows disconsolately and even suicide attempts.Obviously in some cases have exercise-induced agitation and anxiety.Severe cases can experience hallucinations,delusions and other psychotic symptoms.World Health Organization figures show that as many as 1 million people commit suicide because of depression every year.A investigation on an article in 2009 estimated that depressive patients in china had reached 90 million.The mechanism of the antidepressant effect of vortioxetine is thought to be related to its enhancement of serotonergic activity in the CNS through inhibition of the reuptake of serotonin,A large number of clinical researches have confirmed that vortioxetine has good efficacy,safety and tolerability.The design idea of this paper is that Benzothiazole(compound 1)was reacted with 2-bromo-1,4-dimethylbenzene to get compound 2.For the second step the compound 2 was reacted with bis(2-chloroethyl)amine hydrochloride to get title compound.The paper is also explanding the copper-catalyzed coupling reactions.Copper-catalyzed reactions offer a powerful tool for the formation of carbon-heteroatom bonds.Copper catalysis has an indisputable advantage over the other catalytic systems due to its low cost and the use of readily accessible and stable ligands.Among the various copper-catalyzed coupling reactions,C-S bond forming reactions have gained much attention due to its applications in the synthesis of molecules having biological and pharmaceutical impact.This review illustrates the current strategies and applications of Cu-catalyzed C-S cross coupling reactions.