Application Of Exhaled Nitric Oxide Detection In The Stratification Management Of Patients With Cough Variant Asthma

Objective:To evaluate the application value of fractional exhaled nitric oxide(FeNO)detection in the stratification management of patients with cough variant asthma.Methods:On the basis of FeNO level measured before treatment,80 patients with cough variant asthma were equally assigned into two groups of A(FeNO>50 ppb)and B(FeNO<50 ppb),who were treated with budesonide and formoterol fumarate powder for inhalation.The patients of group A were treated with conventional dosage(group A 1,20 cases)or high dosage(group A2,20 cases).The patients of group B were treated with conventional dosage(group B1,20 cases)or low dosage(group B2,20 cases).The cough symptom scores and FeNO levels were compared before and after treatment.Results:The improvement of cough symptom scores on the 4th,8th and 12th week during treatment was better in group A2 than that in group A1(2.71±0.65 vs.3.31±0.77,1.23±0.4 vs.3.21±0.87,and 0.99±0.54 vs.2.89±0.69,all P<0.05),which was not significantly different between groups of B1 and B2(P>0.05).The decrease of FeNO levels on the 8th and 12th week during treatment was more in group A2 than that in group A 1(30.33±5.78 vs.57.32±9.2,and(18.45±6.23vs.55.49±7.90,P<0.01),which was not significantly different between groups of B1 and B2(P>0.05).Conclusion:FeNO detection has an important value in the stratification management of patients with cough variant asthma,who may benefit from FeNO detection by selecting the optimized dosage regimen.