The Clinical Significance Of Circulating MicroRNA-1268 Expression In Lung Cancer

Objective: To discuss the expression of circulating miRNA-1268 in lung cancer plasma,and to analyze its diagnostic and prognostic evaluation value in lung cancer.Method: Real-time fluorescent quantitative PCR was used to detect the relative expression level of circulating miRNA-1268 in 39 lung cancer patients plasma(cancer group)and 39 healthy people plasma(control group).Results: 1.The expression of miRNA-1268 in the cancer group was up-regulated compared with the control group(P<0.05).2.The area under the ROC curve was 0.680,and the 95%CI was 0.562-0.799(P<0.01),its sensitivity in the diagnosis of lung cancer was 74.4% and its specificity was 59.0% when the relative expression level of circulating miRNA-1268 was 0.054.3.The expression of miRNA-1268 was related to tumor stage(P<0.05),and no obvious correlation was found between the expression of miRNA-1268 and some pathological characteristics such as gender,age,smoke,CEA,tumor size,lymph node metastasis and tissue typing.4.Kaplan and Meier analysis results show that there was significant difference between the expression of plasma miR-1268 and overall survival of lung cancer.Patients with high expression of miRNA-1268 showed shorter survival than those with low expression of mi RNA-1268(P<0.05).Conclusion: The up-regulated expression of circulating miRNA-1268 has certain value in the diagnosis and prognostic evaluation of lung cancer,and it may be a useful diagnostic and prognostic biomarker for lung cancer.