Study On The Correlation Between Syndrome And Objective Index Of Infertility Patients With Azoospermia

Objective:To study the distribution of TCM syndromes and the quantitative diagnosis of TCM syndromes in infertility patients,and to explore the correlation between syndrome and objective indicators.Methods:Using the research methods of epidemiology,the reproductive medicine clinic of Henan Traditional Chinese Medicine Hospital of azoospermia case information registration,the information collected includes TCM syndrome types,four diagnostic information,physical examination and test indicators,fill out the clinical observation table,select the Microsoft Office Excel 2007 software to establish a database,and all data entry and proofreading,and finally through the SPSS 22 software for statistical analysis,management,statistical methods including descriptive statistics,rank sum test,factor analysis,linearly related,summary statistics,conclusion.Results:1.209 cases of of the total number of cases;bilateral testicular dysplasia cases were 111 people,accounting for 53.11% of the total number of unilateral testicular dysplasia cases were 3,The number of 1.44%.Bilateral epididymal nodules or swollen patients with 20 people,accounting for 9.57% of the total number of unilateral epididymal nodules or swollen number of 24 cases,accounting for 11.48% of the total number of bilateral epididymis absent or atrophy Of the number of cases of 2 people,accounting for 0.96% of the total number of unilateral epididymal absent or atrophy of the number of 6 people,accounting for 2.87% of the total number.Varicocele patients with 103,accounting for 49.28% of the total number of unilateral vas deferens absent cases of 7 cases,accounting for 3.35% of the total number of bilateral vas deferens absent cases for 3 people,the total number of 1.44 %.2.There were 34 cases(16.27%)of patients with abnormal chromosome karyotype.Among them,47 and XXY were 15,accounting for 7.18%.There were 27 patients with Y chromosome microdeletion abnormality,accounting for 12.91% of the total number;Cases,accounting for 9.09%.3.209 patients were divided into normal group and testicular dysplasia group,serum FSH,LH,T difference between the two groups,with statistical significance(P<0.01),PRL between the two groups was not statistically significant(P>0.05).The size of testis was negatively correlated with serum FSH and LH,and it was positively correlated with serum T(P<0.01).There was no significant difference between the two groups(P>0.05).4.Semen plasma biochemical indicators of the first three abnormal low-seminal ?-glucosidase,low-precision fructose,high-precision alkaline acid phosphatase;low seminal plasma ?-glucosidase value of 141 cases,accounting for 67.46% Berries were 58 cases,accounting for 27.75%;high plasma alkaline phosphatase 41 cases,accounting for 19.62%.5.There were 116 cases(55.5%)of the abnormal protein of chondrocyte,of which 45 cases were implicit infection,accounting for 21.53%,71 cases(33.97%)were confirmed.6.Syndrome frequency from high to low followed by kidney essence deficiency syndrome,kidney deficiency syndrome,blood stasis syndrome,damp heat syndrome,kidney yin deficiency,other;kidney essence deficiency syndrome 87 cases,the total 41.63%,40 cases of Kidney-Yang deficiency syndrome,accounting for 19.14% of the total;37 cases of blood stasis syndrome,accounting for 17.70% of the total;24 cases of damp-heat syndrome,accounting for 11.48% of the total;Accounting for 7.66% of the total;the other 5 cases,accounting for 2.39% of the total.7.The factor analysis of the extraction of azoospermia common Chinese medicine syndrome has 4,respectively,blood stasis card,kidney-yang deficiency,kidney essence deficiency,damp-heat syndrome.The main symptoms of blood stasis syndrome pulse astringent,tongue ecchymosis,dark tongue,testicular bulge,tingling,urinary stinging,skin a mistake,abdominal bulge,perineal bulge,moss white,thin fur;The main symptoms of Kidney-Yang Deficiency Syndrome is aversion to cold,urinary Qing long,pale tongue,nocturia frequency,lower extremity edema,looking white,low back pain,moss thin;Kidney essence deficiency syndrome is the main testicular small Impotence,tooth loose,the spirit of blunt,moss less;damp-heat syndrome is the main symptoms of pulse slip,scrotal dampness,bloating abdominal swelling,nausea,bones,abdominal distension,nausea,limb swelling,dizziness,headache,dizziness,loss of appetite,Trapped heavy,urethral burning,red tongue.8.Abnormal chromosome karyotype patients with the characteristics of the distribution of syndromes for the kidney essence deficiency> kidney yang deficiency> damp heat syndrome> blood stasis card = kidney yin deficiency = other;chromosome karyotype in the distribution of syndromes There was significant difference(P<0.05).9.Y chromosome microdeletion gene abnormalities of the syndromes of the characteristics of the kidney essence deficiency syndrome>kidney yang deficiency> kidney yin deficiency syndrome>blood stasis syndrome = damp heat syndrome = other;Y chromosome microdeletion gene in the TCM card There was no significant difference in the distribution(P>0.05).10.Abnormal sex hormone indicators appear in the top 5 frequency,respectively,high FSH value,high LH value,high PRL value,high E2 value,low T value.The difference of serum FSH,LH,T,PRL between the syndromes was statistically significant(P<0.01),E2 was not statistically significant(P>0.05).11.Abnormal seminal plasma biochemical indicators appeared in the top three frequency,namely low seminal plasma ?-glucosidase value,low seminal pulp fructose value,high seminal plasma ACP value.There was no significant difference in the levels of seminal plasma acid phosphatase,seminal plasma zinc,seminal plasma fructose and seminal plasma ?-glucosidase(P>0.05).12.There was no significant difference in the rate of elastase in seminal plasma(P>0.05).Conclusion:1.The size of testis was negatively correlated with serum FSH and LH,and serum T was positively correlated.2.47,XXY type is the most common abnormal chromosome karyotype,AZFc region is the most common loss of Y chromosome region;abnormal chromosomal patients,kidney essence deficiency syndrome are the most common type,followed by kidney yang deficiency.3.Kidney essence deficiency is 209 cases of azoospermia patients the most common syndrome,followed by kidney yang deficiency,blood stasis syndrome.4.In this study,the quantitative diagnosis of four syndromes of azoospermia has good clinical diagnostic performance and is helpful in guiding clinical syndrome differentiation.5.There were significant differences in chromosome karyotype and serum FSH,LH,T and PRL in 6 syndromes of azoospermia.