Study On Compatibility Of Prescriptions For Treating Senile Dementia In Recent 25 Years

Objective:By collecting and sorting out the prescription for the treatment of senile dementia in the nearly 25 years(1990-2015)of modern literature,using data mining methods,to analyze the prescription compatibility rules for treating senile dementia in the past 25 years,in order to provide ideas and methods for clinical treatment of senile dementia.Methods:1.Collect and sort out the prescription for treating senile dementia by searching.2.Set up Excel data tables for the prepared prescription according to the classification of main therapeutic evidence types,statistical classification of each type of drug,high frequency drug,drug conversion,drug properties;the association rules of each type of drug were analyzed,and the commonly used drug groups were obtained.Results:Through the collection of literature on the treatment of senile dementia in the past 25 years,there were 565 prescriptions,and the common syndrome types were summarized as the insufficiency of the medullary sea type(220),spleen and kidney deficiency type(61),Qi and lood deficiency type(33),turbid phlegm type(76),blood stasis type(99),phlegm stasis type(45),heart and liver fire type(31).The drug classification statistics for each type of medicine entered in the Excel data table can be obtained by:the treatment of the insufficiency of the medullary sea type of senile dementia is based on Blood drug and blood circulation drug,it is mainly combined with Yang drug,Yin drug;the treatment of spleen and kidney deficiency type of senile dementia is based on Qi drug and Yang drug,it is mainly combined with dispelling internal cold drug,Blood drug,water infiltration and dampness drug;the treatment of Qi and blood deficiency type of senile dementia is based on Qi drug,it is mainly combined with sedative drug,Blood drug;the treatment of turbid phlegm type of senile dementia is based on aphlegm and cough drug and Qi drug,it is mainly combined with regulating Qi drug,blood circulation drug;the treatment of blood stasis type of senile dementia is based on blood circulation drug,it is mainly combined with Qi drug,clearing heat drug,Blood drug;the treatment of phlegm and blood stasis type of senile dementia is based on blood circulation drug and phlegm and cough drug,it is mainly combined with regulating Qi drug,Qi drug;the treatment of heart and liver fire type of senile dementia is based on the basic structure of with clearing heat drug,it is mainly combined with peaceful liver wind drug,sedative drug.It can be obtained by analyzing the association rules of each drug type,the commonly used two drugs combination for the the insufficiency of the medullary sea type are Cooked Rehmannia Root-Cornus Fruit,Cooked Rehmannia Root-Acorus Root,Acorus Root-Chinese Senega Root,the commonly used three drugs combination are Acorus Root-Chinese Senega Root-Cooked Rehmannia Root,Acorus Root-Cornus Fruit-Cooked Rehmannia Root,Acorus Root-Chinese Senega Root-Cornus Fruit;the commonly used two drugs combination for the spleen and kidney deficiency typeare Cornus Fruit-Poria,Cornus Fruit-Dioscorea Root,Dioscorea Root-Poria,the commonly used three drugs combination are Poria-Dioscorea Root-Cornus Fruit,Cooked Rehmannia Root-Poria-Dioscorea Root,Cornus Fruit-Cooked Rehmannia Root-Poria;the commonly used two drugs combination for the Qi and blood deficiency type are White Atractylodes Rhizome-Astragalus,Astragalus-Chinese Senega Root,White Atractylodes Rhizome-Chinese Angelica Root,the commonly used three drugs combination are White Atractylodes Rhizome-Astragalus-Chinese Senega Root,Chinese Angelica Root-White Atractylodes Rhizome-Astragalus,Licorice Root-White Atractylodes Rhizome-Astragalus;the commonly used two drugs combination for the turbid phlegm type are Pinellia Rhizome-Orange Peel,Pinellia Rhizome-Acorus Root,Poria-Pinellia Rhizome,the commonly used three drugs combination are Pinellia Rhizome-Orange Peel-Acorus Root,Poria-Acorus Root-Pinellia Rhizome,Pinellia Rhizome-Poria-Orange Peel;the commonly used two drugs combination for the blood stasis type are Red Peony Root-Peach Kernel,Peach Kernel-Safflower Flower,Red Peony Root-Szechuan Lovage Root,the commonly used three drugs combination are Safflower Flower-Szechuan Lovage Root-Peach Kernel,Peach Kernel-Red Peony Root-Szechuan Lovage Root,Peach Kernel-Safflower Flower-Red Peony Root;the commonly used two drugs combination for the phlegm stasis type are Pinellia Rhizome-Orange Peel,Pinellia Rhizome-Acorus Root,Szechuan Lovage Root-Acorus Root,the commonly used three drugs combination are Pinellia Rhizome-Orange Peel-Acorus Root,Jack-in-the-Pulpit Rhizome&Bile-Pinellia Rhizome-Acorus Root,Safflower Flower-Peach Kernel-Szechuan Lovage Root;the commonly used two drugs combination for the heart and liver fire type are Baical Skullcap Root-Gardenia,Gastrodia-Gambir Vine Stems and Thorns,Baical Skullcap Root-Acorus Root,the commonly used three drugs combination are Gastrodia-Abalone Shell-Gambir Vine Stems and Thorns,Gardenia-Coptis Rhizome-Baical Skullcap Root,Spiny Jujube Kernel-Baical Skullcap Root-Acorus Root.In terms of overall medication use,the regression of drugs is mainly Liver,lung,spleen,kidney meridian;the medicinal is mainly warm,cold and flat;most of the drug taste is sweet,bitter,xin;the therapeutic drugs are mainly blood circulation drug,tonic drug and sedative drug.Conclusion:The results suggest that:(1)The insufficiency of the medullary sea type is mainly based on supplementing and removing blood stasis;the spleen and kidney deficiency type is mainly based on Qi and Yang;the Qi and blood deficiency type is mainly based on Qi;the phlegm stasis type is mainly based on resolve phlegmand Qi;the blood stasis type is mainly based on removing blood stasis;the phlegm stasis type is mainly based on resolve phlegm,removing blood stasis;the heart and liver fire type is mainly based on go to the hot.(2)In the drug pair,in addition to the spleen and kidney deficiency type and the Qi and blood deficiency type,the other five syndromes have the use of Acorus Root in the two and three drugs combination,it can be seen that Acorus Root is a common drug for the treatment of senile dementia,it plays an important role in the treatment of senile dementia.(3)The supplementing and exorcising method runs through the treatment process.