Hp-infected Chronic Atrophic Gastritis TCM Syndrome Correlation With Pathological Changes Of Gastric Mucosa

Objective:To explore the correlation between TCM syndrome elements of chronic atrophic gastritis with Hp infection and pathological changes of gastric mucosa,supplement the theory of microscopic syndrome differentiation,and provide guidance for delaying or blocking gastric mucosal lesions more effectively.Methods:120 patients with chronic atrophic gastritis who met the standards were divided into two groups,Hp group including 60 patients with Hp infection and Non-Hp group including 60 uninfected patients through questionnaires.Spss 20.0 software was used for the establishment of the database and comparing two groups’ human distribution and differences of pathological manifestations of gastric mucosa.The syndrome element theory was used to explore the correlation between chronic atrophic gastritis with Hp infection and pathological changes of gastric mucosa.Results:1.There were no significant abnormalities in sex ratio of the Hp group and the Non-Hp group,and the middle age were the most common in the age distribution,followed by the old people,and the young people were less.The average age was not significantly different.2.Common syndrome elements were listed as followed,with the most common one on the left and the least commen one on the right:Nature of disease of the Hp group:qi stagnation,dampness,phlegm(qi deficiency),yang deficiency,hot,yin deficiency,dyspepsia,blood stasis,blood deficiency,hyperactivity of yang,cold(fluid-retention),damage of essence;disease location:stomach,spleen,liver,kidney,large intestine,gallbladder(mind),small intestine,lung,uterus.Nature of disease of the Non-Hp group:qi stagnation,qi deficiency(dampness),yang deficiency,phlegm,yin deficiency,dyspepsia,blood stasis,hot,blood deficiency,hyperactivity of yang,cold,heat in blood,fluid retention,and depletion of fluid(qi sinking);disease location:stomach,spleen,liver,kidney,mind,heart(gallbladder),uterus,small intestine,large intestine,table.3.Differences in pathological severity of gastric mucosa:Compared with the Non-Hp group,the Hp group was closely related to chronic inflammatory reaction,activity and atrophy degree(P<0.05);however,there was no significant correlation of intestinal metaplasia and intraepithelial neoplasia between two groups(both P>0.05).4.Characteristics of syndrome elements of chronic atrophic gastritis with Hp infection and pathological changes of gastric mucosa:Nature of disease "phlegm "," dampness " and "hot" had diversities in the grade distribution of chronic atrophic gastritis with Hp infection(P<0.05),but there was no significant differences in disease location(P>0.05).Nature of disease of Chronic atrophic gastritis with Hp infection " phlegm ","dampness " and "hot" were closely related to the chronic inflammatory reaction,activity and atrophy degree(P<0.05),but there was no difference in intestinal metaplasia in gastric mucosa and intraepithelial neoplasia(P>0.05).5.The characteristics of the syndromes in the two groups of precancerous lesions:pathological spasm and blood stasis are risk factors for cancerous lesions in the Hp group(OR＞1).Conclusion:1.In the Hp group,nature of disease was mixed with the actual situation,and the main deficiency syndromes were qi deficiency and yang deficiency,and the main sufficiency syndromes were qi stagnation,dampness and phlegm;disease location’s syndromes were most closely related to the stomach,spleen and liver.2."phlegm "," dampness " and "hot" were closely related to chronic atrophic gastritis with Hp infection.Chronic atrophic gastritis with Hp infection "phlegm "," dampness " and "hot" were closely related to the chronic inflammatory reaction of gastric mucosa,activity and atrophy degree.It was an important factor in pathological changes of gastric mucosa.