The Correlation Between The Body Fat Percentage And Body Mass Index With The Propofol Dosage

Objective:To investigate the effect of body fat percentage and body mass index(BMI)on the propofol infusion amounts in patients,and to obtain a simple formula for the dosage of propofol.Methods:A total of 104 patients undergoing elective laparoscopic surgery were enrolled(aged 25-59 years and ASA grade I-II).The patients were divided into 4 groups: A(normal BMI and body fat percentage),B(normal BMI and high body fat percentage),C(high BMI and normal body fat percentage),and D(high BMI and body fat percentage).All patients were treated with a unified anesthesia program,and the bispectral index was controlled around 50.The anesthesia-induction propofol dosage,anesthesia-maintenance propofol dosage and extubation time were recorded.All the gender,BMI and body fat percentage were used to construct multiple linear regression models.Results:The anesthesia-induction propofol dosage of group D was higher than those of group A?B?C(P<0.05);The anesthesia-maintenance propofol dosage in first 1 and2 hours of group B and D were lower than that in group A(P<0.05),the dosage of propofol in group A and group C was no significant difference(P > 0.05),also the dosage of propofol in group A and group C(P > 0.05);the four groups had no significant difference in extubation time(P > 0.05).The regression formula was as follows: first hour propofol dosage(mg/kg)= 7.715 + 1.900 * gender(0,1)-0.125 *body fat percentage(male 0,female 1).Conclusion:The patients with higher BMI or body fat percentage use lower dosages of propofol during anesthesia-maintenance.When the BMI contradict body fat percentage to measure obesity,the body fat percentage has a better correlation withthe propofol dosage in patients.