The Correlational Study Between Middle Cerebral Artery Hemodynamics And Cerebral Small Vessel Disease Of Cognitive Impairment

Objesctive:To study the The Correlational between middle cerebral artery Hemodynamics and cerebral small vessel disease of cognitive impairment.Methods:100 patients with cerebral small vessel disease and 100 healthy subjects participated in the current study,whose age,sex and education were matched.Montreal Cognitive Assessment(MoCA)、 Fuld Object-Memory Evaluation(FOM)、 Rapid verbal retrieve(RVR)、 Block Design(BD)、 Digit Span(DS)、 Alzheimer’s disease assessment scale-cognitive(ADASCog)、 Symbol Digit Modalities Test(SDMT)、middle cerebral artery Hemodynamics Was used for evaluation.Results: The scores of FOM,RVR,ADAS-Cog,DS and SDMT were significantly lower in patients with CSVD than those in the control group,with statistical significance(P < 0.05).In terms of hemodynamics,Vm and PI in LMCA of Vm and PI and RMCA in CSVD patients were significantly higher than those in control group,with statistical significance(P < 0.05).In patients with CSVD,the hemodynamics of cognitive impairment group and cognitive normal group were significantly higher than those of CSVD group in PI and PI of MCA(P < 0.05).There was no difference between the Vm of LMCA and the Vm of RMCA(P > 0.05).Conclusion: Cognitive impairment of CSVD is characterized by impaired cognitive domain,which is more serious with attention,executive ability,immediate recollection and word recognition.Vm and PI in MCA may be related to the pathogenesis of CSVD.There is no significant correlation between cognitive function level and mean blood flow velocity of middle cerebral artery in patients with CSVD,and the cognitive function level in patients with CSVD is related to the middle cerebral artery fluctuation index.