Relationship Between Nuclear Factor-κB Signaling Pathway And Susceptibility Of Recurrent Aphthous Ulcer

Objective To explore the possible relationship between recurrent aphthous ulcer(RAU)and nuclear factor-κB signaling pathway.Methods A total of 124 RAU patients were recruited for this study.The control group consisted of 133 subjects.NFκBp50,NFκBp65,IκBαand IKK serum concentration were detected by ELISA.NFκB-94 ins/del ATTG sites were detected by restriction fragment length polymorphism-polymerase chain reaction(PCR-RFLP).The Hardy-Weinberg equilibrium can inspect groups’ representative.All statistical analysis was performed using the SPSS 20.0statistical package.The measurement data were analyzed by t test and χ2 test.Results1.NFκB p50,NFκB p65 and IKK levels in serum of the patients were significantly lower than those of the controls(P <0.05).IκBα levels in serum of the patients were significantly higher than those of the controls(P <0.05).2.In the control group,the genotype frequencies of NFκB-94 ins/del ATTG site conform with the Hardy-Weinberg equilibrium,and have a group’s representative.3.NFκB-94 ins/del ATTG :In this study,we found 2 alleles which are allele I and allele D,and3 genotypes which are genotype II,genotype ID and genotype DD.There was statistically significant difference in the frequencies of NFκB-94 ins/del ATTGgenotypes and alleles between the RAU patients and healthy controls,and the frequencyof the allele D in the RAU group is higher than in the healthy controls.P <0.05.Conclusion1.NF kappa B signaling pathway is associated with RAU.2.The polymorphism of the NFκB-94 ins/del ATTG was associated with RAU.