Clinical Study On The Effect Of Xiaoaiping Injection On Coagulation Function In Patients With Advanced Tumor Chemotherapy

ObjectiveIn this research,non-small cell lung cancer(NSCLC) and gastric cancer patients in advanced stage are taken as the object of research and the changes of blood coagula tion related parameters such as PT、PTT、TT、FIB、D-D of the chemotherapy alon e group (control group) and chemotherapy combined with XiaoAiPing injection group (experimental group) were observed before and after the treatment to evaluate the effe ct of chemotherapy and XiaoAiPing injection on the blood coagulation parameters in t he above mentioned patients.MethodsThe project of "A clinical study of the effect of XiaoAiPing injection on platelet and its parameters from peripheral blood in chemotherapy cancer patients" uses rand omized controlled trial (RCT) research method to divide the eligible patients who met the inclusion criteria into the experimental and control group.The chemotherapy regim ens and drug dosages of both groups are determined according to the NCCN guidelin e and the experimental group received the combination of chemotherapy and XiaAoPi ng injection of 60ml daily,given intravenously after diluted in 5% or 10% Glucose sol ution,once a day,dl to d10,and observed for 21 days.The patients’data were collected at different visiting points.This research organizes and analyses the data of blood coa gulation related parameters of 81 complete cases of visiting point 1 and 4 in this pro ject,which include 39 patients in experimental group and 42 patients in control group.ResultsThe blood coagulation related parameters in control group were compared within the group before and after the treatment and found that the difference has no statistic al significance (P>0.05),however the PT exceeded the normal reference range and has the tendency of prolongation.The blood coagulation related parameters in experiment group were compared within the group before and after the treatment and found that the difference has no statistical significance (P> 0.05).The blood coagulation related pa rameters in both groups were compared between the groups and found that the differe nce has no statistical significance (P>0.05).Both groups have no incidence of thromb oembolism during the treatment.Subgroup analysis:①The blood coagulation related para meters of patients aged≤65 years old in control group were compared within the gro up before and after the treatment and found that the difference has no statistical signi ficance (P>0.05),however the PT in experimental group has exceeded the normal refe rence range and has the tendency of prolongation.The blood coagulation related param eters in both groups were compared between the groups before and after the treatmen t and found that the difference has no statistical significance (P>0.05).②The blood c oagulation related parameters of patients aged>65 years old in control group and exp eriment group were compared within the group before and after the treatment and fou nd that the difference has no statistical significance (P>0.05).The blood coagulation r elated parameters in both groups were compared between the groups before and after the treatment and found that the difference has no statistical significance (P>0.05).③ The blood coagulation related parameters of NSCLC patients in control group and exp eriment group were compared within the group before and after the treatment and fou nd that the difference has no statistical significance (P>0.05).However the PT in cont rol group has exceeded the normal reference range after the chemotherapy and has th e tendency of prolongation.The FIB of experiment group has exceeded the normal ref erence range before the chemotherapy and returned to normal reference range after th e chemotherapy and has the tendency of reduction.The blood coagulation related para meters in both groups were compared between the groups before and after the treatm ent and found that the difference has no statistical significance (P>0.05).④The blood coagulation related parameters of gastric cancer patients in control group and experi ment group were compared within the group before and after the treatment and found that the difference has no statistical significance (P>0.05).The blood coagulation rela ted parameters in both groups were compared between the groups before and after the treatment and found that the difference has no statistical significance (P>0.05).⑤The APTT of patient with baseline hypercoagulable state in control group and experiment group were compared within the group before and after the treatment and found that the difference has statistical significance (P<0.05),however the value before and after the treatment is still within the normal reference range,hence this does not explain c hemotherapy will cause the prolongation of APTT in patient with baseline hypercoagul able state.The blood coagulation related parameters in experiment group were compare d within the group before and after the treatment and found that the difference has n o statistical significance (P>0.05).The blood coagulation related parameters in both gr oups were compared between the groups before and after the treatment and found tha t the difference has no statistical significance (P>0.05).ConclusionsThe result of the study has shown that:①ne cycle of chemotherapy has the ten dency to extend PT of advanced stage NSCLC and gastric cancer patient and this mi ght be related to age and disease.②One cycle of chemotherapy combined with XiaoAi Ping injection has the tendency to reduce abnormal FIB in advanced stage NSCLC pa tient and no effect on other blood coagulation related parameters.③One cycle of chem otherapy combined with XiaoAiPing injection has not increased the risk of thromboem bolism in advanced stage NSCLC and gastric cancer patient...