Objective:To evaluate the efficacy and safety of Huatanjieyu prescription in the treatment of vertigo symptom of posterior circulation transient ischemic attack (syndrome of phlegm heat disturbance),and to provide scientific basis for its clinical application.Methods:Using random number table method,sixty patients who met the inclusion criteria of posterior circulation transient ischemic attack(syndrome of phlegm heat disturbance) were randomly divided into two groups,the proportion of the two groups was 1:1,each group had thirty cases.The experimental group was given a dose of Huatanjieyu prescription three times daily on the basic drugs,and was given a tablet Betahistine Mesilate Tablets three times daily at the same time;The control group was given a tablet Betahistine Mesilate Tablets three times daily on the basic drugs.Treatment for two weeks.Before treatment and after two weeks,scoring respectively TCM syndrome scale,Dizziness Handicap Inventory(DHI) and European Evaluation of Vertigo Scale,examining TCD ultrasound, recording the Mean velocity(Vm) and Pulsation index(PI) of bilateral vertebral artery and basilar artery, evaluating the safety through observing vital signs and adverse reaction during the trials.Results:(1)Comparison of TCM syndrome scale score:After treatment of two weeks, the scores of the experimental group and the control group were all decreased,there was statistically significant difference within each group(P< 0.05),there was statistically significant difference between the two groups(P<0.05),the total effective rate of the experimental group was 93.10%, the control group was 60.71%,there was statistically significant difference(P<0.05),the efficacy of the experimental group was better than the control group.(2)Comparison of DHI score.After treatment of two weeks, the scores of the experimental group and the control group were all decreased,there was statistically significant difference within each group(P<0.05), there was statistically significant difference between the two groups(P< 0.05),each factor score of DHI was all decreased,there was statistically significant difference within each group(P< 0.05),there was statistically significant difference between the two groups(P< 0.05),the total effective rate of the experimental group was 79.31%,the control group was 53.57%,there was statistically significant difference (P<0.05),the efficacy of the experimental group was better than the control group.(3) Comparison of European Evaluation of Vertigo Scale score:After treatment of two weeks, the scores of the experimental group and the control group were all decreased,there was statistically significant difference within each group(P< 0.05), there was statistically significant difference between the two groups(P< 0.05),the total effective rate of the experimental group was 89.66%, the control group was 60.71%,there was statistically significant difference(P< 0.05),the efficacy of the experimental group was better than the control group.(4)Comparison of TCD ultrasound:After treatment of two weeks,the Vm and PI of left vertebral artery were all improved,there was statistically significant difference within each group(P<0.05), there was no statistically significant difference between the two groups(P>0.05),in the improvement of Vm and PI of left vertebral artery,the efficacy was equivalent between the two groups; After treatment of two weeks, the Vm and PI of right vertebral artery and basilar artery were all improved,there was statistically significant difference within each group(P<0.05), there was statistically significant difference between the two groups(P<0.05),in the improvement of the Vm and PI of right vertebral artery and basilar artery,the experimental group was better than the control group.(5)During the trials, no abnormal change was found in the vital signs of the two groups, and no obvious adverse reaction was found.Conclusion:Huatanjieyu prescription could significantly reduce TCM syndrome scale,Dizziness Handicap Inventory(DHI) and European Evaluation of Vertigo Scale score of posterior circulation transient ischemic attack(syndrome of phlegm heat disturbance),and it could improve the relevant indicators of TCD ultrasound examination,and there was not obvious adverse reaction. |