The Clinical Study Of "analogous Selection Of Drugs" Linfang Compounding And Reducing The Moistening Muscle Cream For The Treatment Of White Blood Stasis Syndrome

Psoriasis vulgaris,"baibi disease" in Chinese medicine,is a multi-system inflammatory disease,mainly manifested in skin and joints.The basic skin damage for this disease is multi-layer silver white scales covering on the basis of erythema.The duration of this disease is long,with patient’s condition waving,lingering and difficult to cure.When severe condition occurs,the whole body shows large amount of erythema desquamation,which affects the beauty of appearance.The skin with dryness,hypertrophy and intolerable itching brings serious physical and mental effects to the patient.Due to complex treatment and caring,adding the difficulty in balancing the curative efficacy and safety,psoriasis has become one of the most commonly and stubborn disease in dermatology with focus study.Chinese medicine decoction can be made by selecting Chinese herbs and making prescriptions based on patient’s symptoms,which is a good interpretation of the advantages of ’"processing according to prescriptions".However,the ingredients of drugs for external application are fixed currently,and cannot "individually" customized based on patient’s symptoms,which has a certain limitation effect in improving patient’s symptoms.This clinical observation summarized the experience of the founder of traditional Chinese medicine(TCM)Professor Zhao Bingnan and contemporary TCM masters in treating psoriasis.According to the external treatment of baibi disease in TCM classics and the theatrical guidance of Professor Deng Bingxu"s "analogy selection" theory and processed accordingly,combined with the experience of prescription for external application in dermatology department,Runji ointment in Essential Teachings on External Medicine was selected as basic prescription,and was prescribed according to the symptom characteristics of patients with baibi disease of blood dryness syndrome,so as to conduct systematic efficacy evaluation on baibi disease of blood dryness syndrome,and objectively evaluate the curative effect in treating baibi disease by "analogy selection" theory.OBJECTIVE:To objectively evaluate the clinical efficacy and safety of the treatment of baibi disease(psoriasis vulgaris)with blood dryness syndrome with modified Runji ointment,inherit and carry forward the academic thoughts of TCM external treatment,so as to expand the theory and practice level of TCM external treatment.METHODS:A method of random and parallel control was used.The patients with left and right symmetrical lesions were selected as the target lesions,and the random number table was used to divide symmetrical lesions into treatment group and control group,giving treatment of modified Runji ointment and placebo ointment respectively.The efficacy evaluation and target skin lesions photography were performed every two weeks for four times with treatment course lasting eight weeks.The efficacy determination and safety testing were conducted after eight weeks.The primary evaluation indexes were skin lesion area and severity index,and the secondary evaluation indexes includes skin barrier function test,visual analogue score(VAS),target lesion area,dermatology quality of life index(DLQI),health status questionnaire(SF-36),the main clinical symptoms of TCM indicators.Results:A total of 50 patients were collected in this clinical observation,and 48 of 50 patients completed which including 27 cases of male patients,21 cases of female patients;45 cases of married patients,3 cases of unmarried patients.There were 22 patients with a family history of psoriasis.Among them,there was no be cured patient.33 cases were improved with 18 male patients and 15 female patients.15 cases were showing curative effects with 8 male patients and 7 female patients.2 cases were showing no efficacy with 1 male patient and 1 female patient and there was no cured patient.The cure rate was 4%,32%was showing effect with effective rate of 48%.The overall efficiency was 84%.After 8 weeks’ treatment,patients had significant differences in TCM symptoms,DLQI,VAS,BAS,SF-36 compared with that before treatment(P<0.05).Conclusion:The modified Runji ointment is safe and effective in the treatment of psoriasis vulgaris,which is a new attempt to externally treat psoriasis.