| Objective:To analyze the characteristics and influencing factors of diurnal blood pressure of hypertensive patients on the basis of 24 h ambulatory blood pressure data.Method:312 essential hypertensive patients were selected to conduct ambulatory blood pressure monitoring(ABPM)for 24h.According to the ages<40 group?40?49 group?50?59 group and ?60 group were divided to analyze the impact of age and gender on the blood pressure and early morning blood pressure in hypertensive patients.Results:The proportion of dipper type,non-dipper type,anti-dipping type and super-dipper blood pressure patients among the 312 is 45.19%,41.35%,7.37%and 6.09%,respectively.The proportion of dipper type blood pressure in the young group of<40 years old is the highest(65.00%).The proportion of anti-dipping type blood pressure in the old group of ?60 years old is the highest(18.92%).The average age of patients with dipper blood pressure was 51.09 ±6.61 years,and the average age of non dipper patients was 54.35±5.73 years old.Gender had no significant effect on blood pressure type.Only the proportion of men with anti-dipping type blood pressure is lower than women with that(P<0.01).There are no statistically significances for the differences of other types between the two groups.The proportion of morning hypertension is as high as 96.5%among 312 patients.Age has no significant effect on the proportion of morning hypertension,while gender has an effect on the proportion of morning hypertension:the detection rate of male group is significantly higher than that of female group(P<0.05).Conclusion:The proportion of abnormal blood pressure and rhythm in elderly patients is higher.Morning hypertension is more likely to occur in male patients.Individualized antihypertensive regimen should be formulated on the basis of circadian rhythm of blood pressure in patientsObjective:24-hour ambulatory blood pressure data was summarized in 165 patients with essential hypertension(EH)in Outpatient department of Fuwai Hospital.Analyzed their features of six hypotensors in aspects of morning blood pressure,blood pressure type,T/P ratio and smoothness index to provide evidences for clinical antihypertensive treatments.Methods:165 patients with essential hypertension accepted treatments in Fuwai Hospital Outpatient from October,2003 to January,2005 were selected.After 2 weeks of placebo wash-out period,these 6 groups were treated respectively with amlodipine,benazepril,valsartan,metoprolol,torasemide and terazosin.8 weeks later,165 patients were qualified to accept ambulatory blood pressure monitors.Results:The antihypertensive effects on systolic pressure and diastolic pressure of the amlodipine group were significantly better than those of other groups,especially in the aspect of morning blood pressure on which had the most prominent antihypertensive effects.Metoprolol could effectively decrease the morning blood pressure too,while other 4 drugs(benazepril,valsartan,torasemide,terazosin)didn't possess this function.Although all 6 groups showed antihypertensive effects in various degrees,the proportion of dipper hypertensive patients after drug administration didn't significantly increase which means the circadian rhythm of blood pressure wasn't obviously restored.The T/P ratio of amlodipine group was significantly better than those of other groups.The T/P ratio of systolic pressure and diastolic pressure of valsartan,benazepril and metoprolol groups decreased successively,while all above 50%.The T/P ratio of torasemide and terazosin groups were lower than 50%.The SI of amlodipine group in systolic pressure and diastolic pressure were all significantly higher than those of other groups.Conclusion:The 6 hypotensors could decrease hypertensive patients' blood pressure in different degree.Their effects on morning blood pressure were different,while the effects on blood pressure type were not significant.The sustainability and stability of those hypotensors had some differences with each other too. |
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