| Objective To study how brain activity of Type 2 diabetes mellitus(T2DM)changes with time by using Regional Homogeneity(ReHo)Methods Twenty-five T2DM patients and 24 healthy controls have been recruited through advertising.Clinical and biochemical datas of all the subjects have been acquisited spectively between November to September in 2012 and 2015,multidimensional neuropsychological tests and resting state fMRI(rest-state functional magnetic resonance imaging,rs-fMRI)have also been put on all the subjects.The rs-fMRI images have been preprocessed in Matlab workbench,and we have distilled the brain ares of which activity is higher than the global brain average activity of the two groups in both years.Paired sample t tests have been taken on SPSS 19.0 to detect whether the clinical and biochemical datas and neuropsychological test scores in 2015 were different from those in 2012,paired sample t tests have been taken on the REST software package in Matlab workbench to detect whether the ReHo values of both groups were different from those of baseline.ReHo values and clinical datas of the two different years were compared and to explore whether ReHo value was related to clinical variables.Results1.Forty-nine volunteers have been recruited,excepting subjects whose heads were moving too much and who have losted to follow-up the study,eventually 22 T2DM patients and 12 healthy controls were involved in the 3 years follow-up study.The fasting glucose,fasting insulin,glycosylated hemoglobin,blood sugar triglyceride,total cholesterol,systolic blood pressure and waist circumference of T2DM patients in 2015 were increased from 2012,but there were no significant differences beteen the two years(p>0.05);The triglycerides,total cholesterol,systolic blood pressure of the control group were increased from 2012,the fasting glucose,fasting insulin,glycosylated hemoglobin were slightly lower than those in 2012,but there were no significant differences beteen the two years(p>0.05)2.The MoCA scores,AVLT scores,CFT delay scores of T2DM patients in 2015 were reduced from 2012,the CFT delayed scores were significant lower than those of 2012,TMT-A and TMT-B were higher than those in 2012,but there was no significant difference(p>0.05);The MoCA scores,AVLT scores,CFT delay scores of T2DM patients in 2015 were reduced from 2012,the TMT －A and TMT-B were higher than those in 2012,but there was no significant difference(p>0.05).3.Rest-based paired sample t test showed that the ReHo values of the bilateral occipital lobe and right frontal of the T2DM patients were significantly reduced than those of 2012(p<0.01,Alphasim correction);The ReHo values of the right precuneu of normal control subjects were significantly lower than those in 2012,the ReHo value of the right frontal is significantly higher than in 2012(P<0.01,Alphasim correction).4.Correlation analysis showed that the change of ReHo values in left occipitai lobe was closely related to the changes of CFT-delayed scores and TMT-B of the T2DM patients.(r = 0.52,p = 0.02;r = 0.46,p = 0.04)there were no significant correlations between the changes of the ReHo values in the right occipital lobe and left frontal and changes of the clinical variables changes and cognitive function test scores.The ReHo value changes of the right precuneus and the left frontal gyrus had no significant correction from the changes of the clinical variable and the cognitive function test scores of normal subjects.Conclusion1.The memory,executive capability and information processing speed have been declined by age of the old people whether they have T2DM;2.The visual memory declined significantly of the T2DM patients in three years;3.The brain function of the bilateral occipital lobes in T2DM patients continued to reduce and have not presentes higher brain function compensatory area in 3 years;4.The decent of activity in the left occipital lobe of T2DM patients were significantly carrelated with the visual memory decline and the lower of information grocessing speed. |
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