Silver Promotoed Synthesis Of Trifluoromethyl Thioindenones And Thiofluoroacetamides

Fluorine-containing compounds are important in organic synthesis and widely applied in medicine,pesticides,materials and other fields.Therefore,the methods to introduce various fluorine-containing functional groups into organic molecules have been favored by chemists.This thesis mainly introduced the construction of fluorine-containing functional groups with sulfur atoms and developed new method for the synthesis of trifluoromethylthio fluorenones and thiotrifluoromethylamides.The thesis three parts:(1)The different trifluoromethylthiolation reactions via radical,eletrophilic or nucleophilic process,and the synthesis of indenones were summarized.The synthesis of thioamides was introduced according to the sulfur sources.(2)The method for the synthesis of 2-(trifluoromethylthio)-indenones has been developed by silver-mediated cascade trifluoromethylthiolation/cyclization of arylpropynones.It has the merits of simple and economic procedure,broad functional group compatibility.(3)Copper-catalyzed three component coupling reaction of imine,sulfur and CFC-113 a for thesynthesis of trifluorothioacetamides has been developed.It also provided a new safe disposal method for environmentally persistent Freon.This route can also be applied to the synthsis of tetrahydroisoquinoline.