| Orthopedic implant placement site infection is one of the most serious complications of orthopedic surgery,ranging from the delay in treatment of patients with the cycle,increasing treatment costs,but also lead to the patient amputation or death due to infection.There are two main reasons for the infection at the site of implantation:one is that the bacteria adhere to the surface of the implant to form a biofilm,and the biofilm hinder the immune response of the body and the killing effect of antibiotics on the bacteria.Second,due to the poor biocompatibility of the implant material,it is difficult to form a firm bond with the host bone.Therefore,it is of great significance to improve the antimicrobial performance of orthopedic implants in the existing industries in order to enhance the life span of orthopedic implants and enhance the industry of high-end orthopedic implants with independent intellectual property rights.The primary means of imparting antibacterial properties to orthopedic implants is efficient loading and controlled release of antibacterial agents in the coating material.Titanium and titanium alloys are the most widely used implant materials,and the TiO2 coating formed on the surface can be used as a carrier for antibacterial agents.Among the antibacterial agents,silver has broad-spectrum antibacterial ability,and has the advantages of low cytotoxicity.The nano-scale silver particles have high specific surface area,increased probability of contact with bacteria,and easy bonding of the surface atoms with other chemical groups to prepare a stable silver nano-composite.Therefore,it is possible to obtain long-term antibacterial properties while being biocompatible by loading the nano-silver particles in the titania-coated pore structure and controlling the release rate thereof.In this paper,titanium dioxide coating was prepared on the surface of implant based on industrial electrochemical technique.The loading of silver nanoparticles was investigated by surface modification and photochemical-reduction.The biological function of titanium dioxide-nanosilver composite coating was systematically investigated.The content is as follows:Chapter 1:Briefly introduced the postoperative response and biological function of the orthopedic implant materials,and introduced the application of titanium and titanium alloy in the orthopedic implant and several surface modification methods.At the same time,the classification and application of antibacterial materials and the mechanism and application status of silver antibacterial agents were introduced.Finally,the research progress of antimicrobial titanium coating is reviewed.Chapter 2:Brief introduction of the main raw materials and test analysis means,such as XRD,SEM,TEM,FTIR,microplate reader.Chapter 3:Titanium dioxide nanotubes were prepared on the surface of titanium by anodic oxidation,and titania nanotubes with controlled diameter were obtained.Then titanium dioxide nanotubes prepared by anodic oxidation were surface-modified with polydopamine and then impregnated with UV light to obtain titanium dioxide nanotubes loaded with silver nanoparticles.The results showed that silver nanoparticles with controlled loading and good Wetting AgNPs/TNTs coating material.Chapter 4:We prepared a porous titanium oxide coating on the titanium surface by micro-arc oxidation,and obtained a titania coating with controlled surface morphology.The surface of titanium dioxide coating was modified,and then the micro-arc oxidation titania coating with silver nano-particles was prepared by impregnation method and UV-light reduction method.AgNPs/TiO2 coating material with controlled silver nano-particles loading and good wettability were obtained.Chapter 5:We prepared by the above two methods of titanium dioxide-nano-silver(TiO2-Ag)composite coating.TiO2-Ag composite coating surface treatment methods,the sustained release performance of silver ions are also different.Polydopamine modified TiO2-Ag composite coating silver nanoparticles loading was significantly improved,compared with non-polydopamine modified coating,the modified coating is more conducive to the release of silver ions.Compared with the porous Ti02 obtained by micro-arc oxidation,the silver nanotubes loaded with Ti02 nanotubes obtained by anodic oxidation are more conducive to the sustained release of silver ions.The sustained-release properties of silver ions have the following results:NTs-PD-Ag>NTs-Ag>MAO-PD-Ag>MAO-Ag.And the right amount of silver nanoparticles loaded TiO2-Ag composite coating material has good antibacterial properties and biocompatibility.Chapter 6:We summarize the research results of this topic and puts forward the prospect of future research. |
PDF Full Text Request