Synthesis Of Alkyne Copper Cluster Compounds And Detection Of Small Biological Molecules

Objective Our goal in the paper is to synthesize a series of alkyne copper cluster compounds and research their catalytic activity for small biological molecules.In order to get novel sensing material which have excellent sensitivity and selectivity activity based on alkyne copper cluster compound.Methods The novel alkyne copper cluster compounds have been prepared by conventional solvent method and solvothermal method.The novel alkyne copper cluster compounds were characterized by X-ray diffraction,IR and elemental analysis.The catalytic activity of alkyne copper cluster compounds for H₂O₂ and citric acid has been studied by UV-vis spectrophotometer.Results The four alkynyl copper cluster compounds were synthesized by introducing different kinds of silver salts with tert-butyne alkyne as the precursor.The UV response of the compounds to hydrogen peroxide and citric acid was systematically studied.For hydrogen peroxide,the detection range of compound 1⁴ was 9⁵0μmol?L^-1,10⁵2μmol?L^-1,10⁵0μmol?L^-11 and 10⁵0μmol?L^-1.The detection limit of compound 1⁴ was 0.98μmol?L^-1,5.62μmol?L^-1,2.36μmol?L^-11 and 4.72μmol?L^-1.For citric acid,the detection range of compound 1⁴was 9⁷5μmol?L^-1,7⁶1μmol?L^-1,6⁷5μmol?L^-11 and 9⁹0μmol?L^-1.The detection limit of compound 1⁴ was 2.79μmol?L^-1,3.57μmol?L^-1,0.29μmol?L^-1,and 1.65μmol?L^-1,respectively.Conclusions The material ratio and reaction temperature for the syntheses of compound1⁴ were the key factors.In the catalytic reactions between hydrogen peroxide and citric acid,the copper cluster with more copper atoms showed the stronger the redox property with the lower the detection limit during the catalytic reactions.For the detection of citric acid,compound 1⁴ showed a lower detection limit.The successful preparation of the compounds provides a new structural model and basic data for the development of small biological molecule sensor.