Preparation Process And Quality Standard Research Of Suchangshi Tongfeng Capsule

Suchangshi Tongfeng Capsule is respectively in Simiao Sun,Kentang Wang "Bei ji qian jin yao fang","Zheng zhi zhun sheng"(volume of seven "Feng du jiao qi",because of quotations from Changshi Su of the party,the original called "Zhu yu tang",renamed the "Su changshi zhuyu tang" and a clinical efficacy in "Jiao qi lun" on cure athlete’s foot is swollen with disease),on the basis of a clear etiology by our many years of clinical experience and to add and subtract the cut after the screening.Is composed of two kinds of evodia rutaecarpa and papaya,with pain,lishi,the effect of detumescence,in view of gouty arthritis,better clinical curative effect,which is widely used.This topic main research: Preparation process and Quality standard research of Suchangshi Tongfeng Capsule.Research on preparation technology,first is to extract process.According to the preparation of the active constituents of evodia rutaecarpa contained,whose nature poorly soluble in water,with a certain concentration of ethanol extraction.First,the individual factors affecting extraction;Orthogonal technology was studied again,comprehensive extraction effect of each factor to affect the outcome.With the comprehensive influence the optimal extraction process and the actual production balance.Finally selected the optimum extraction process for: 55% ethanol reflux extraction twice(the first time: 12 times the amount of extract 50 min,the second time: 4 times the amount of extracted 30 min).Followed by purification process,the first relief recycled ethanol;Again for filtration,centrifugal,macroporous resin respectively three methods of examining the effects of liquid,the filtering and centrifugal way of removing impurity content had no obvious impact on the major ingredients,and macroporous resin purification effect is quite good.So eventually selected the optimum purification process for the sample liquid concentration on: 0.5018 g/ml(diluted concentrate about double);Elution volume: 10 BV;Elution velocity: 2 BV/h.Finally,the molding process,use first beta cyclodextrin inclusion,and optimizing molding materials and its dosage,respectively at the same time examines the preparation of wetting agent concentration,grain drying temperature and time.Molding process for the final is: the purified powder(g): beta cyclodextrin(g)=1:1 blending→90℃ ultrasonic bag 90 min→dried medicinal herbs(g): dextrin(g)=1-0.5(80% ethanol as a wetting agent)mixing→granulating→drying oven(60℃)in the dry 2 h→whole grain→loaded 0# capsule.To study the preparation of quality standards: first established the medicine yinpian thin layer identification method(TLC): papaya;To establish the content determination method(HPLC)and HPLC: evodia alkaloid and evodia rutaecarpa alkali.To determine the quality of the process is reasonable,quality control standards.